Fluorine-18 and medical imaging: Radiopharmaceuticals for positron emission tomography

被引：101
作者：
Le Bars, Didier [1 ]
机构：
[1] Univ Lyon, UMR 5181, Cermep Imagerie Vivant, F-69677 Bron, France
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2006年 / 127卷 / 11期
关键词：
fluorine-18; radiopharmaceuticals; labelled compounds; positron emission tomography;
D O I：
10.1016/j.jfluchem.2006.09.015
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Fluorine presents among its radioactive isotopes fluorine-18, that decays with a 109 min half-life and a beta(+) emission, allowing external detection of the two coincident gamma photons obtained after annihilation. Production techniques (medical cyclotron), radiochemical reactions for isotope incorporation in radiopharmaceuticals and development of specific detection cameras (positron emission tomographs) allowed development of a vast investigation field in medical imaging. Applications of PET in oncology ([F-18]fluorodeoxyglucose, FDG) largely improved detection and management of cancers; tracer molecules labelled with fluorine-18 also allow fruitful researches in molecular imaging. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：1488 / 1493
页数：6
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