Regioselective Three-Component Synthesis of Vicinal Diamines via 1,2-Diamination of Styrenes

被引：26
作者：
Cao, Jie [1 ,2 ]
Lv, Daqi [1 ,2 ]
Yu, Fei [2 ]
Chiou, Mong-Feng [2 ]
Li, Yajun [2 ]
Bao, Hongli [2 ]
机构：
[1] Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China
[2] Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter,State Key Lab Struc, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350002, Fujian, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 08期
关键词：
CATALYTIC ASYMMETRIC DIAMINATION; METAL-FREE DIAMINATION; CONJUGATED DIENES; INTERMOLECULAR 1,2-DIAMINATION; PD(0)-CATALYZED DIAMINATION; TERMINAL OLEFINS; ALKENES; DIFUNCTIONALIZATION; FUNCTIONALIZATION; AZODICARBOXYLATE;
D O I：
10.1021/acs.orglett.1c00898
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The vicinal diamine motif plays a significant role in natural products, drug design, and organic synthesis, and development of synthetic methods for the synthesis of diamines is a long-standing interest. Herein, we report a regioselective intermolecular three-component vicinal diamination of styrenes with acetonitrile and azodicarboxylates. The diamination products can be produced in moderate to excellent yields via the Ritter reaction. Synthetic applications and theoretical studies of this reaction have been conducted.
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收藏
页码：3184 / 3189
页数：6
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