The innate immunity of guinea pigs against highly pathogenic avian influenza virus infection

被引：9

作者：

Zhang, Kun ^{[1
,2
]}

Xu, Wei wei ^{[1
]}

Zhang, Zhaowei ^{[1
]}

Liu, Jing ^{[1
]}

Li, Jing ^{[3
]}

Sun, Lijuan ^{[4
]}

Sun, Weiyang ^{[1
]}

Jiao, Peirong ^{[5
]}

Sang, Xiaoyu ^{[1
]}

Ren, Zhiguang ^{[1
]}

Yu, Zhijun ^{[1
]}

Li, Yuanguo ^{[1
]}

Feng, Na ^{[1
]}

Wang, Tiecheng ^{[1
]}

Wang, Hualei ^{[1
]}

Yang, Songtao ^{[1
]}

Zhao, Yongkun ^{[1
]}

Zhang, Xuemei ^{[4
]}

Wilker, Peter R. ^{[6
]}

Liu, WenJun ^{[3
]}

Liao, Ming ^{[5
]}

Chen, Hualan ^{[7
]}

Gao, Yuwei ^{[1
]}

Xia, Xianzhu ^{[1
]}

机构：

[1] Acad Mil Med Sci, Mil Vet Inst, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China

[2] Virginia Commonwealth Univ, Sch Dent, Philips Inst Oral Hlth Res, Richmond, VA 23298 USA

[3] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China

[4] Changchun Inst Biol Prod, Dept Influenza Vaccine, Changchun 130062, Peoples R China

[5] South China Agr Univ, Coll Vet Med, Guangzhou, Guangdong, Peoples R China

[6] Univ Wisconsin La Crosse, Dept Microbiol, La Crosse, WI 54601 USA

[7] Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 18期

基金：

中国国家自然科学基金;

关键词：

innate immunity; guinea pig; highly pathogenic avian influenza virus; GBP-1; RIG-I; 1ST PROTEOME PROFILES; ALVEOLAR MACROPHAGES; BETA-INTERFERON; ISOBARIC TAGS; HOST-DEFENSE; COMPLEMENT; TRANSMISSION; MODEL; INHIBITION; APOPTOSIS;

D O I：

10.18632/oncotarget.16503

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

H5N1 avian influenza viruses are a major pandemic concern. In contrast to the highly virulent phenotype of H5N1 in humans and many animal models, guinea pigs do not typically display signs of severe disease in response to H5N1 virus infection. Here, proteomic and transcriptional profiling were applied to identify host factors that account for the observed attenuation of A/Tiger/Harbin/01/2002 (H5N1) virulence in guinea pigs. RIG-I and numerous interferon stimulated genes were among host proteins with altered expression in guinea pig lungs during H5N1 infection. Overexpression of RIG-I or the RIG-I adaptor protein MAVS in guinea pig cell lines inhibited H5N1 replication. Endogenous GBP-1 expression was required for RIG-I mediated inhibition of viral replication upstream of the activity of MAVS. Furthermore, we show that guinea pig complement is involved in viral clearance, the regulation of inflammation, and cellular apoptosis during influenza virus infection of guinea pigs. This work uncovers features of the guinea pig innate immune response to influenza that may render guinea pigs resistant to highly pathogenic influenza viruses.

引用

页码：30422 / 30437

页数：16

共 69 条

[1] The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA [J].

Allen, Irving C. ;

Scull, Margaret A. ;

Moore, Chris B. ;

Holl, Eda K. ;

McElvania-TeKippe, Erin ;

Taxman, Debra J. ;

Guthrie, Elizabeth H. ;

Pickles, Raymond J. ;

Ting, Jenny P. -Y. .

IMMUNITY, 2009, 30 (04) :556-565

[2] Integrated molecular signature of disease: Analysis of influenza virus-infected macaques through functional genomics and proteomics [J].

Baas, T. ;

Baskin, C. R. ;

Diamond, D. L. ;

Garcia-Sastre, A. ;

Bielefeldt-Ohmann, H. ;

Tumpey, T. M. ;

Thomas, M. J. ;

Carter, V. S. ;

Teal, T. H. ;

Van Hoeven, N. ;

Proll, S. ;

Jacobs, J. M. ;

Caldwelll, Z. R. ;

Gritsenko, M. A. ;

Hukkanen, R. R. ;

Camp, D. G., II ;

Smith, R. D. ;

Katze, M. G. .

JOURNAL OF VIROLOGY, 2006, 80 (21) :10813-10828

[3] Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus [J].

Baskin, Carole R. ;

Bielefeldt-Ohmann, Helle ;

Tumpey, Terrence M. ;

Sabourin, Patrick J. ;

Long, James P. ;

Garcia-Sastre, Adolfo ;

Tolnay, Airn-E. ;

Albrecht, Randy ;

Pyles, John A. ;

Olson, Pam H. ;

Aicher, Lauri D. ;

Rosenzweig, Elizabeth R. ;

Murali-Krishna, Kaja ;

Clark, Edward A. ;

Kotur, Mark S. ;

Fornek, Jamie L. ;

Proll, Sean ;

Palermo, Robert E. ;

Sabourin, Carol L. ;

Katze, Michael G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) :3455-3460

[4] Host Genetic Variation Affects Resistance to Infection with a Highly Pathogenic H5N1 Influenza A Virus in Mice [J].

Boon, Adrianus C. M. ;

deBeauchamp, Jennifer ;

Hollmann, Anna ;

Luke, Jennifer ;

Kotb, Malak ;

Rowe, Sarah ;

Finkelstein, David ;

Neale, Geoffrey ;

Lu, Lu ;

Williams, Robert W. ;

Webby, Richard J. .

JOURNAL OF VIROLOGY, 2009, 83 (20) :10417-10426

[5] A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection [J].

Brandes, Marlene ;

Klauschen, Frederick ;

Kuchen, Stefan ;

Germain, Ronald N. .

CELL, 2013, 154 (01) :197-212

[6] Macaque Proteome Response to Highly Pathogenic Avian Influenza and 1918 Reassortant Influenza Virus Infections [J].

Brown, Joseph N. ;

Palermo, Robert E. ;

Baskin, Carole R. ;

Gritsenko, Marina ;

Sabourin, Patrick J. ;

Long, James P. ;

Sabourin, Carol L. ;

Bielefeldt-Ohmann, Helle ;

Garcia-Sastre, Adolfo ;

Albrecht, Randy ;

Tumpey, Terrence M. ;

Jacobs, Jon M. ;

Smith, Richard D. ;

Katze, Michael G. .

JOURNAL OF VIROLOGY, 2010, 84 (22) :12058-12068

[7] Gene Expression Analysis of Host Innate Immune Responses during Lethal H5N1 Infection in Ferrets [J].

Cameron, Cheryl M. ;

Cameron, Mark J. ;

Bermejo-Martin, Jesus F. ;

Ran, Longsi ;

Xu, Luoling ;

Turner, Patricia V. ;

Ran, Ran ;

Danesh, Ali ;

Fang, Yuan ;

Chan, Pak-Kei M. ;

Mytle, Nutan ;

Sullivan, Timothy J. ;

Collins, Tassie L. ;

Johnson, Michael G. ;

Medina, Julio C. ;

Rowe, Thomas ;

Kelvin, David J. .

JOURNAL OF VIROLOGY, 2008, 82 (22) :11308-11317

[8] Hsp90 inhibitors reduce influenza virus replication in cell culture [J].

Chase, Geoffrey ;

Deng, Tao ;

Fodor, Ervin ;

Leung, Bo Wah ;

Mayer, Daniel ;

Schwemmle, Martin ;

Brownlee, George .

VIROLOGY, 2008, 377 (02) :431-439

[9] Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? [J].

Cheung, CY ;

Poon, LLM ;

Lau, AS ;

Luk, W ;

Lau, YL ;

Shortridge, KF ;

Gordon, S ;

Guan, Y ;

Peiris, JSM .

LANCET, 2002, 360 (9348) :1831-1837

[10] Lethal Dissemination of H5N1 Influenza Virus Is Associated with Dysregulation of Inflammation and Lipoxin Signaling in a Mouse Model of Infection [J].

Cilloniz, Cristian ;

Pantin-Jackwood, Mary J. ;

Ni, Chester ;

Goodman, Alan G. ;

Peng, Xinxia ;

Proll, Sean C. ;

Carter, Victoria S. ;

Rosenzweig, Elizabeth R. ;

Szretter, Kristy J. ;

Katz, Jacqueline M. ;

Korth, Marcus J. ;

Swayne, David E. ;

Tumpey, Terrence M. ;

Katze, Michael G. .

JOURNAL OF VIROLOGY, 2010, 84 (15) :7613-7624

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