A [4+1] annulation of ortho-electrophile-substituted para-quinone methides for the synthesis of indanes and isoindolines

被引：14
作者：
Feng, Ziwen [1 ,2 ]
Yuan, Zhenbo [1 ,2 ]
Zhao, Xiaobin [1 ,2 ]
Huang, Yue [3 ]
Yao, Hequan [1 ,2 ]
机构：
[1] China Pharmaceut Univ, SKLNM, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China
[3] China Pharmaceut Univ, Sch Sci, Dept Organ Chem, Nanjing 21000, Jiangsu, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2019年 / 6卷 / 20期
基金：
中国国家自然科学基金;
关键词：
ASYMMETRIC 1,6-CONJUGATE ADDITION; ENANTIOSELECTIVE SYNTHESIS; 1,2,3-TRISUBSTITUTED INDANES; DIASTEREOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ACID; SPIROCYCLOPROPANATION; INDANONES; ARYL;
D O I：
10.1039/c9qo00977a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A [4 + 1] annulation between newly designed ortho-electrophile-substituted para-quinone methides and nucleophiles through tandem 1,6-conjugated addition/1,4-Michael addition under mild reaction conditions has been described. This reaction provides an efficient method to construct indanes and isoindolines in moderate to good yields and with good functional group tolerance.
引用
收藏
页码：3535 / 3539
页数：5
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