MDM2 alternative splicing is regulated by microRNA binding to control p53 activity

被引：1
|
作者：
Montes, Matias [1 ,2 ]
Goodwin, Andrew [2 ]
Chandler, Dawn S. [1 ,2 ]
机构：
[1] Ohio State Univ, Columbus, OH 43210 USA
[2] Nationwide Childrens Hosp, Columbus, OH USA
来源：
CANCER RESEARCH | 2019年 / 79卷 / 13期
关键词：
D O I：
10.1158/1538-7445.AM2019-4506
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4506
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4
    Chandler, Dawn S.
    Singh, Ravi K.
    Caldwell, Lisa C.
    Bitler, Jaquelyn L.
    Lozan, Guillermina
    CANCER RESEARCH, 2006, 66 (19) : 9502 - 9508
  • [2] Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation
    Kulikov, Roman
    Winter, Markus
    Blattner, Christine
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (39) : 28575 - 28583
  • [3] Binding of an inhibitor of the p53/MDM2 interaction to MDM2
    Duncan, SJ
    Cooper, MA
    Williams, DH
    CHEMICAL COMMUNICATIONS, 2003, (03) : 316 - 317
  • [4] Coordinately regulated alternative splicing of the p53 modulators mdm2 and mdm4 is an evolutionarily conserved damage response
    Chandler, Dawn S.
    Caldwell, Lisa C.
    Evans, Susan C.
    Lozano, Guillermina
    CANCER RESEARCH, 2006, 66 (08)
  • [5] MDM2 alternative splicing: fine-tuning the p53 damage response
    Jacob, Aishwarya G.
    Singh, Ravi K.
    Bebee, Thomas W.
    Chandler, Dawn S.
    CANCER RESEARCH, 2012, 72
  • [6] Autoregulation of the p53 Binding Activity of Mdm2 by Intrinsically Disordered Regions
    Ferrolino, M. C.
    Phillips, A. H.
    Kriwacki, R. W.
    PROTEIN SCIENCE, 2016, 25 : 112 - 112
  • [7] Regulation of p53 and MDM2 activity by MTBP
    Brady, M
    Vlatkovic, N
    Boyd, MT
    MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (02) : 545 - 553
  • [8] The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo
    Huang, Lei
    Yan, Zheng
    Liao, Xiaodong
    Li, Yuan
    Yang, Jie
    Wang, Zhu-Gang
    Zuo, Yong
    Kawai, Hidehiko
    Shadfan, Miriam
    Ganapathy, Suthakar
    Yuan, Zhi-Min
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (29) : 12001 - 12006
  • [9] Mdm2: Keeping p53 under control
    Piette, J
    Neel, H
    Marechal, V
    ONCOGENE, 1997, 15 (09) : 1001 - 1010
  • [10] Mdm2: keeping p53 under control
    Jacques Piette
    Henry Neel
    Vincent Maréchal
    Oncogene, 1997, 15 : 1001 - 1010
12345