Impact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies

被引：14

作者：

Chouairi, Fouad ^{[1
]}

Mullan, Clancy W. ^{[1
,2
]}

Sen, Sounok ^{[1
,3
]}

Mori, Makoto ^{[1
,2
]}

Fuery, Michael ^{[1
,3
]}

Elder, Robert W. ^{[4
,5
]}

Lesse, Joshua ^{[3
]}

Norton, Kelsey ^{[3
]}

Clark, Katherine A. ^{[1
,3
]}

Miller, P. Elliott ^{[1
,3
]}

Mulligan, David ^{[1
,5
]}

Formica, Richard ^{[1
,6
]}

Rogers, Joseph G. ^{[7
]}

Jacoby, Daniel ^{[1
,3
]}

Maulion, Christopher ^{[1
,3
]}

Anwer, Muhammad ^{[1
,2
]}

Geirsson, Arnar ^{[1
,2
]}

Desai, Nihar R. ^{[1
,3
]}

Ahmad, Tariq ^{[1
,3
]}

机构：

[1] Yale Sch Med, New Haven, CT 06510 USA

[2] Yale Sch Med, Div Cardiac Surg, New Haven, CT USA

[3] Yale Sch Med, Sect Cardiovasc Med, New Haven, CT 06510 USA

[4] Yale Sch Med, Sect Pediat Cardiol, New Haven, CT USA

[5] Yale Sch Med, Div Transplantat, New Haven, CT USA

[6] Yale Sch Med, Sect Nephrol, New Haven, CT USA

[7] Duke Univ, Med Ctr, Div Cardiol, Durham, NC 27710 USA

来源：

PLOS ONE | 2021年 / 16卷 / 03期

关键词：

D O I：

10.1371/journal.pone.0247789

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Patients with restrictive or hypertrophic cardiomyopathy (RCM/HCM) and congenital heart disease (CHD) do not derive clinical benefit from inotropes and mechanical circulatory support. Concerns were expressed that the new heart allocation system implemented in October 2018 would disadvantage these patients. This paper aimed to examine the impact of the new adult heart allocation system on transplantation and outcomes among patients with RCM/HCM/CHD. Methods We identified adult patients with RCM/HCM/CHD in the United Network for Organ Sharing (UNOS) database who were listed for or received a cardiac transplant from April 2017-June 2020. The cohort was separated into those listed before and after allocation system changes. Demographics and recipient characteristics, donor characteristics, waitlist survival, and post-transplantation outcomes were analyzed. Results The number of patients listed for RCM/HCM/CHD increased after the allocation system change from 429 to 517. Prior to the change, the majority RCM/HCM/CHD patients were Status 1A at time of transplantation; afterwards, most were Status 2. Wait times decreased significantly for all: RCM (41 days vs 27 days; P<0.05), HCM (55 days vs 38 days; P<0.05), CHD (81 days vs 49 days; P<0.05). Distance traveled increased for all: RCM (76 mi. vs 261 mi, P<0.001), HCM (88 mi. vs 231 mi. P<0.001), CHD (114 mi vs 199 mi, P<0.05). Rates of transplantation were higher for RCM and CHD (P<0.01), whereas post-transplant survival remained unchanged. Conclusions The new allocation system has had a positive impact on time to transplantation of patients with RCM, HCM, and CHD without negatively influencing survival.

引用

页数：10

共 16 条

[1] Outcomes in Patients With Hypertrophic Cardiomyopathy Awaiting Heart Transplantation [J].