Treatment of radiation-induced dermatitis with light-emitting diode (LED) photomodulation

被引：84
作者：
DeLand, M. Maitland
Weiss, Robert A.
McDaniel, David H.
Geronemus, Roy G.
机构：
[1] Maryland Laser Skin & Vein Inst LLC, Hunt Valley, MD 21030 USA
[2] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA
[3] Eastern Virginia Med Sch, Inst Antiaging Res, Virginia Beach, VA USA
[4] NYU Med Ctr, Laser & Skin Surg Ctr New York, New York, NY 10016 USA
[5] Oncol Inc, Lafayette, LA USA
[6] Louisiana State Univ, Sch Med, Lafayette, LA USA
来源：
LASERS IN SURGERY AND MEDICINE | 2007年 / 39卷 / 02期
关键词：
breast cancer; fibroblast; IMRT; irradiation; low-intensity light; skin reaction; LED; photomodulation;
D O I：
10.1002/lsm.20455
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background and Objective: Light-emitting diode (LED) photomodulation increases dermal collagen and reduces inflammation. This study evaluated the use of LED photomodulation in the prevention of radiation-induced dermatitis in breast cancer. Materials and Methods: Patients (n = 19) were treated with LED photomodulation (Gentlewaves(TM), Light BioScience, LLC, Virginia Beach, VA) after each of a series of intensity-modulated radiation treatments (IMRT). Skin reactions were monitored weekly with National Cancer Institute (NCI) criteria. Age-matched controls (n = 28) received IMRT without LED photomodulation. Results: In LED-treated patients, 18 (94.7%) had grade 0 or 1 reaction and 1 (5.3%) had grade 2 reaction. Among controls, 4 (14.3%) had a grade 1 reaction, 24 (85.7%) had a grade 2 or 3 reaction. One LED-treated patient (5.3%) and 19 controls (67.9%) had to interrupt treatment. Conclusion: LED photomodulation treatments immediately after IMRT reduces the incidence of NCI grades 1, 2, and 3 skin reactions in patients with breast cancer treated by radiation therapy (RT) postlumpectomy.
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收藏
页码：164 / 168
页数：5
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