Endocrine-responsive breast cancer and strategies for combating resistance

被引：702
作者：
Ali, S
Coombes, RC
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Dept Canc Med, London W12 0NN, England
[2] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Canc Res Campaign Labs, London W12 0NN, England
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 02期
关键词：
D O I：
10.1038/nrc721
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Deaths from breast cancer have fallen markedly over the past decade due, in part, to the use of endocrine agents that reduce the levels of circulating oestrogens or compete with oestrogen for binding to its receptor. However, many breast tumours either fail to respond or become resistant to endocrine therapies. By understanding the mechanisms that underlie this resistance, we might be able to develop strategies for overcoming or bypassing it.
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页码：101 / +
页数：13
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