Glycosidase-catalysed synthesis of oligosaccharides: A one step synthesis of lactosamine and of the linear B type 2 trisaccharide alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAcSEt involved in the hyperacute rejection response in xenotransplantation from pigs to man and as the specific receptor for toxin A from Clostridium difficile

被引：39
作者：
Vic, G [1 ]
Tran, CH [1 ]
Scigelova, M [1 ]
Crout, DHG [1 ]
机构：
[1] UNIV WARWICK,DEPT CHEM,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND
来源：
CHEMICAL COMMUNICATIONS | 1997年 / 02期
关键词：
D O I：
10.1039/a607255k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sequential use of the beta-galactosidase from Bacillus circulans and an a-galactosidase from Aspergillus oryzae give the linear B trisaccharide 2, identified as the epitope that binds anti-Gal antibodies during pig-to-man xenotransplantation and as the receptor for toxin A from Clostridium difficile.
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收藏
页码：169 / 170
页数：2
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