Effect of fermented soybean products intake on the overall immune safety and function in mice

被引：18

作者：

Lee, Jae Hee ^{[1
]}

Paek, Se Hee ^{[2
]}

Shin, Hye Won ^{[2
]}

Lee, Seung Yeon ^{[2
]}

Moon, Byoung Seok ^{[2
]}

Park, Jung Eun ^{[1
]}

Lim, Gyeong Dong ^{[1
]}

Kim, Chang Yul ^{[1
]}

Heo, Yong ^{[1
]}

机构：

[1] Catholic Univ Daegu, Dept Occupat Hlth, Gyongsan 38430, South Korea

[2] CJ CheilJedang Corp, Foods Res Inst, Suwon 16495, South Korea

来源：

JOURNAL OF VETERINARY SCIENCE | 2017年 / 18卷 / 01期

关键词：

cheonggukjang; doenjang; immunity; mice; soybean products; INTERFERON-GAMMA; SOY ISOFLAVONES; FOODS; DOENJANG; CANCER;

D O I：

10.4142/jvs.2017.18.1.25

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Various functional activities have been reported for the fermented soybean products doenjang (DJ) and cheonggukjang (CGJ), although no systemic investigations of their immune functions have been conducted to date. We examined the effects of an experimental diet of DJ, CGJ, or a mixture of unfermented raw material for 4 weeks on overall immunity and immune safety in mice. No significant alterations were observed in peripheral or splenic immune cells among groups. Enhanced splenic natural killer cell activity was observed in the DJ and CGJ groups compared with the plain diet group. T helper type-1 (Thl)-mediated immune responses were enhanced in the DJ and CGJ groups with an upregulated production ratio of IFN-gamma vs. IL-4 and IgG2a vs. IgG1 in stimulated splenic T and B cells, respectively. Resistance to Listeria monocytogenes infection was observed in the DJ and CGJ groups. Overall, the results of this study suggest that DJ and CGJ intake consolidates humoral and cellular immunity to Thl responses.

引用

页码：25 / 32

页数：8

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