T cells in swine completely rearrange immunoglobulin heavy chain genes

被引：10

作者：

Sinkorova, Jana ^{[1
]}

Stepanova, Katerina ^{[1
]}

Butler, John E. ^{[2
]}

Sinkora, Marek ^{[1
]}

机构：

[1] Czech Acad Sci, Inst Microbiol, Lab Gnotobiol, Novy Hradek, Czech Republic

[2] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2019年 / 99卷

关键词：

Porcine immune system; B cell receptors; Gene rearrangement; Lymphocyte repertoire development; Lymphocyte subpopulations; Thymus; ANTIBODY REPERTOIRE DEVELOPMENT; ILEAL PEYERS-PATCHES; NEONATAL PIGLETS; B-CELLS; GERM-FREE; FETAL; EXPRESSION; THYMUS; LYMPHOGENESIS; TRANSCRIPTION;

D O I：

10.1016/j.dci.2019.103396

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Porcine thymus contains three independent populations of cells that have rearranged immunoglobulin heavy chain VDJ(H) genes. The first population can be found exclusively in medulla and it consists of existing mature B cells and plasma cells. The second consists of developing B cells characterized by the presence of selected VDJ(H )rearrangement, similar to B cell lymphogenesis in the bone marrow. The third population is entirely unaffected by selection mechanism for productive VDJ(H )rearrangement and represents T lineage cells that rearrange immunoglobulin genes. Transcription of unselected VDJ(H) repertoire is not allowed in T cells. Sequence analysis of unselected VDJ(H) repertoire from T cells also revealed important consequences for B cell lymphogenesis and selection of B cell repertoire. As far as we know, this is the first evidence that some species completely rearrange VDJ(H )genes in T cells. Our results also support the finding that B cells actively develop in the thymus.

引用

页数：9

共 48 条

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