Repetition suppression and plasticity in the human brain

被引:167
作者
Garrido, Marta I. [1 ,2 ]
Kilner, James M. [2 ]
Kiebel, Stefan J. [3 ]
Stephan, Klaas E. [2 ,4 ]
Baldeweg, Torsten [5 ]
Friston, Karl J. [2 ]
机构
[1] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA
[2] UCL, Wellcome Trust Ctr Neuroimaging, Inst Neurol, London WC1E 6BT, England
[3] Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany
[4] Univ Zurich, Lab Social & Neural Syst Res, Inst Empir Res Econ, CH-8006 Zurich, Switzerland
[5] UCL, Inst Child Hlth, London WC1E 6BT, England
基金
英国惠康基金;
关键词
Connectivity; DCM; EEG; Network; Perceptual learning; MISMATCH NEGATIVITY; EVOKED-RESPONSES; AUDITORY-CORTEX; BAYESIAN-ESTIMATION; SPECTRAL RESPONSES; SOUNDS; MEMORY; ADAPTATION; POTENTIALS; MECHANISMS;
D O I
10.1016/j.neuroimage.2009.06.034
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The suppression of neuronal responses to a repeated event is a ubiquitous phenomenon in neuroscience. However, the underlying mechanisms remain largely unexplored. The aim of this study was to examine the temporal evolution of experience-dependent changes in connectivity induced by repeated stimuli. We recorded event-related potentials (ERPs) during frequency changes of a repeating tone. Bayesian inversion of dynamic causal models (DCM) of ERPs revealed systematic repetition-dependent changes in both intrinsic and extrinsic connections, within a hierarchical cortical network. Critically, these changes occurred very quickly, over interstimulus intervals that implicate short-term synaptic plasticity. Furthermore, intrinsic (within-source) connections showed biphasic changes that were Much faster than changes in extrinsic (between-source) connections, which decreased monotonically with repetition. This study shows that auditory perceptual learning is associated with repetition-dependent plasticity in the human brain. It is remarkable that distinct changes in intrinsic and extrinsic connections could be quantified so reliably and non-invasively using EEG. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:269 / 279
页数:11
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