GlycA, a novel inflammatory marker, is associated with subclinical coronary disease

被引：29

作者：

Tibuakuu, Martin ^{[1
,2
]}

Fashanu, Oluwaseun E. ^{[1
]}

Zhao, Di ^{[3
]}

Otvos, James D. ^{[4
]}

Brown, Todd T. ^{[5
]}

Haberlen, Sabina A. ^{[3
]}

Guallar, Eliseo ^{[3
]}

Budoff, Matthew J. ^{[6
]}

Palella, Frank J., Jr. ^{[7
]}

Martinson, Jeremy J. ^{[8
]}

Akinkuolie, Akintunde O. ^{[9
,10
]}

Mora, Samia ^{[9
]}

Post, Wendy S. ^{[1
,3
]}

Michos, Erin D. ^{[1
,3
]}

机构：

[1] Johns Hopkins Sch Med, Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA

[2] St Lukes Hosp, Dept Med, Chesterfield, MO USA

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21287 USA

[4] LabCorp, Morrisville, NC USA

[5] Johns Hopkins Sch Med, Div Endocrinol Diabet & Metab, Baltimore, MD USA

[6] Los Angeles Biomed Res Inst Harbor UCLA, Los Angeles, CA USA

[7] Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA

[8] Univ Pittsburgh, Dept Infect Dis & Microbiol, Pittsburgh, PA USA

[9] Harvard Med Sch, Brigham & Womens Hosp, Ctr Lipid Metabol, Boston, MA 02115 USA

[10] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

来源：

AIDS | 2019年 / 33卷 / 03期

关键词：

cardiac computed tomography; coronary artery calcium; coronary atherosclerosis; GlycA; HIV infection; inflammation; MULTICENTER AIDS COHORT; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; COMPUTED-TOMOGRAPHY; PREDICTIVE-VALUE; HIV-INFECTION; RISK; ATHEROSCLEROSIS; BIOMARKER; EVENTS;

D O I：

10.1097/QAD.0000000000002079

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: GlycA, a novel NMR biomarker of inflammation, has been associated with incident cardiovascular disease (CVD) in the general population, but its association with CVD among HIV-infected individuals is unknown. We examined the associations between GlycA and subclinical coronary plaque among HIV-infected and HIV-uninfected men participating in Multicenter AIDS Cohort Study (MACS). Design: Cross-sectional analysis of 935 men with plasma measurement of GlycA and noncontrast cardiac computed tomography (CT) and/or coronary CT angiography. Methods: We used multivariable Poisson and linear regression to assess associations of GlycA with prevalent coronary atherosclerosis and plaque extent, respectively. Results: Mean +/- SD age was 54 +/- 7 years; 31% were black; 63% HIV-infected. GlycA levels were higher in HIV-infected compared with HIV-uninfected men (397 +/- 68 vs. 380 +/- 60 mu mol/l, P = 0.0001) and higher for men with detectable viral load vs. undetectable (413 +/- 79 vs. 393 +/- 65 mu mol/l, P = 0.004). After adjusting for HIV serostatus, demographic and CVD risk factors, every 1SD increment in GlycA level was associated with a higher prevalence of coronary artery calcium (CAC > 0) [prevalence ratio 1.09 (95% CI 1.03-1.15)] and coronary stenosis at least 50% [1.20 (1.02-1.41)]. These associations were not significantly altered after adjusting for traditional inflammatory biomarkers or differ by HIV serostatus. Among men with plaque, GlycA was positively associated with the extent of CAC and total plaque. Conclusion: HIV infection was associated with higher GlycA levels. In both HIV-infected and HIV-uninfected individuals, GlycA was significantly associated with several measures of subclinical coronary atherosclerosis, independent of other CVD risk factors and inflammatory biomarkers. These findings suggest the potential role of GlycA in CVD risk stratification among HIV patients. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：547 / 557

页数：11

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