Eph Receptors in the Immunosuppressive Tumor Microenvironment

被引：40
作者：
Janes, Peter W. [1 ]
Vail, Mary E. [1 ]
Ernst, Matthias [2 ]
Scott, Andrew M. [1 ]
机构：
[1] La Trobe Univ, Sch Canc Med, Tumour Targeting Program, Olivia Newton John Canc Inst, Melbourne, Vic, Australia
[2] La Trobe Univ, Sch Canc Med, Canc & Inflammat Program, Olivia Newton John Canc Inst, Melbourne, Vic, Australia
来源：
CANCER RESEARCH | 2021年 / 81卷 / 04期
基金：
英国医学研究理事会;
关键词：
TYROSINE KINASES; BREAST-CANCER; STEM-CELLS; NETWORKS;
D O I：
10.1158/0008-5472.CAN-20-3047
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The tumor microenvironment (TME) promotes tumor development via complex intercellular signaling, aiding tumor growth and suppressing immunity. Eph receptors (Eph) and their ephrin ligands control cell interactions during normal development, and reemerge in tumors and the TME, where they are implicated in invasion, metastasis, and angiogenesis. Recent studies also indicate roles for Ephs in suppressing immune responses by controlling tumor interactions with innate and adaptive immune cells within the TME. Accordingly, inhibiting these functions can promote immune response and efficacy of immune checkpoint inhibition. This research highlights Ephs as potential targets to enhance efficacy of immune-based therapies in patients with cancer.
引用
收藏
页码：801 / 805
页数：5
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