Bioactivity flavonoids from roots of Euphorbia tirucalli L.

被引：13

作者：

de Lima, Maria de Fatima Rocha ^{[1
]}

Cavalcante, Luziene A. ^{[1
]}

Costa, Emily Cintia Tossi de Araujo ^{[4
]}

de Veras, Bruno Oliveira ^{[2
]}

da Silva, Marcia Vanusa ^{[3
]}

Cavalcanti, Livia Nunes ^{[1
]}

Araujo, Renata Mendonca ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Norte, Inst Quim, Lab Isolamento & Sintese Compostos Organ, BR-59072970 Natal, RN, Brazil

[2] Univ Fed Pernambuco, Dept Med Trop, BR-50670901 Recife, PE, Brazil

[3] Univ Fed Pernambuco, Dept Bioquim, BR-50670901 Recife, PE, Brazil

[4] Univ Fed Rio Grande do Norte, Inst Quim, Nucleo Processamento Primario & Reuso Agua Prod N, BR-59078970 Natal, RN, Brazil

来源：

PHYTOCHEMISTRY LETTERS | 2021年 / 41卷

关键词：

Euphorbia tirucalli; Ampelopsin; Myricetin; Phenolic compounds; Antimicrobial activity;

D O I：

10.1016/j.phytol.2020.10.017

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Euphorbia tirucalli (Euphorbiaceae) is a species widely utilized for popular medicine in northeast of Brazil because of its innumerable reported medicinal properties. The HPLC-Qtrap-MS/MS analysis from E. tirucalli roots ethanol extract revealed that this species presents 8 flavonoids and 5 shikimate derivative compounds. Chemical studies of these ethanolic extract using chromatographic procedures allowed the isolation of four previously unreported compounds for this species: myricetin, 3,3'-dimethoxy 4-O-alpha-rhamnopyranoside-ellagic acid, 4-O-methyl-gallic acid and ampelopsin. All structures were determined using 1D and 2D NMR spectroscopy analysis. The ethanol extract and four isolated compounds were evaluated for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Sporothrix brasiliensis and Candida albicans. All the analyzed compounds presented activity against all evaluated bacteria and fungi, with MIC values ranging from 8 to 2048 mu g/mL.

引用

页码：186 / 192

页数：7

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