Detoxification of ionic liquids using glutathione, cysteine, and NADH: Toxicity evaluation by Tetrahymena pyriformis

被引：16

作者：

Cui, Yin Hua ^{[1
]}

Shi, Qing Shan ^{[1
]}

Zhang, Dan Dan ^{[1
]}

Wang, Ling Ling ^{[1
]}

Feng, Jin ^{[1
]}

Chen, Yi Wen ^{[2
]}

Xie, Xiao Bao ^{[1
]}

机构：

[1] Guangdong Acad Sci, Guangdong Inst Microbiol, Guangdong Prov Key Lab Microbial Culture Collect, State Key Lab Appl Microbiol Southern China, Guangzhou 510070, Peoples R China

[2] Guangdong Detect Ctr Microbiol, Guangdong Inst Microbiol, Guangdong Prov Key Lab Microbial Culture Collect, State Key Lab Appl Microbiol Southern China, Guangzhou 510070, Peoples R China

来源：

ENVIRONMENTAL POLLUTION | 2021年 / 276卷

基金：

中国国家自然科学基金;

关键词：

Ionic liquids; Glutathione; Nicotinamide adenine dinucleotide; Cysteine; Reactive oxygen species; Tetrahymena pyriformis; CAENORHABDITIS-ELEGANS; METALLOTHIONEIN; THERMOPHILA; HOMEOSTASIS; PROTEIN; CYTOTOXICITY; INHIBITION; METABOLISM; APOPTOSIS; SELENIUM;

D O I：

10.1016/j.envpol.2021.116725

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Ionic liquids (ILs), also known as green solvents, are widely acknowledged in several fields, such as chemical separation, synthesis, and electrochemistry, owing to their excellent physiochemical properties. However, their poor biodegradability may lead to environmental and health risks, posing a severe threat to humans, thus requiring further research. In this study, the biotoxicities of the imidazolium-based ILs were evaluated in Tetrahymena pyriformis. Moreover, IL detoxification was investigated by addition of glutathione (GSH), cysteine, and nicotinamide adenine dinucleotide (NADH). Reactive oxygen species (ROS) initiated by different IL types caused damage to Tetrahymena, while glutathione, cysteine, and NADH eliminated ROS, achieving the detoxification purposes. Detoxification results showed that NADH exhibited the best detoxification ability, followed by glutathione and cysteine. Finally, RT-PCR results suggested that metallothionein might have participated in IL detoxification. (C) 2020 The Author(s).

引用

页数：10

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