Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material

被引：72

作者：

Karahaliloglu, Zeynep ^{[1
,2
]}

Kilicay, Ebru ^{[3
]}

Denkbas, Emir Baki ^{[4
]}

机构：

[1] Aksaray Univ, Fac Sci, Aksaray, Turkey

[2] Arts Biol Dept, Aksaray, Turkey

[3] Bulent Ecevit Univ, Zonguldak Vocat High Sch, Zonguldak, Turkey

[4] Hacettepe Univ, Biochem Div, Dept Chem, Ankara, Turkey

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 06期

关键词：

Chitosan; lauric acid; silk sericin; wound dressing; zinc oxide nanoparticles; IN-VITRO; NANOCOMPOSITE; MANAGEMENT; MEMBRANES; PROTEIN; CHITIN;

D O I：

10.1080/21691401.2016.1203796

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Antimicrobial mixed dressings have traditionally been used to minimize bacterial infection of burns and other wounds. This study presents the advancement of biocompatible chitosan/silk sericin (CHT/SS) scaffolds combined with lauric acid (LA) and zinc oxide nanoparticles (nZnO) for the successful wound dressing applications. Antibacterial assay results showed that the diameters of the inhibition zone increased from 2 +/- 0.4 to 7 +/- 0.1mm for Escherichia coli, as well as from 2.5 +/- 0.2 to 6 +/- 0.4mm for Staphylococcus aureus while CHTS/SS/100nZnO compared to CHT/SS/0.01LA. The results not only showed excellent inhibition against Gram-positive and Gram-negative bacterial growth but also revealed improved proliferation and extended viability for HaCaT cells.

引用

页码：1172 / 1185

页数：14

共 48 条

[1] Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications [J].

Alves, N. M. ;

Mano, J. F. .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2008, 43 (05) :401-414

[2]

[Anonymous], 2010, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD006478.pub2

[3] A green salt-leaching technique to produce sericin/PVA/glycerin scaffolds with distinguished characteristics for wound-dressing applications [J].

Aramwit, Pornanong ;

Ratanavaraporn, Juthamas ;

Ekgasit, Sanong ;

Tongsakul, Duangta ;

Bang, Nipaporn .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2015, 103 (04) :915-924

[4] Electrospun polycaprolactone/ZnO nanocomposite membranes as biomaterials with antibacterial and cell adhesion properties [J].

Augustine, Robin ;

Malik, Hruda Nanda ;

Singhal, Dinesh Kumar ;

Mukherjee, Ayan ;

Malakar, Dhruba ;

Kalarikkal, Nandakumar ;

Thomas, Sabu .

JOURNAL OF POLYMER RESEARCH, 2014, 21 (03)

[5] Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications [J].

Berger, J ;

Reist, M ;

Mayer, JM ;

Felt, O ;

Peppas, NA ;

Gurny, R .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 57 (01) :19-34

[6] Wound healing dressings and drug delivery systems: A review [J].

Boateng, Joshua S. ;

Matthews, Kerr H. ;

Stevens, Howard N. E. ;

Eccleston, Gillian M. .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (08) :2892-2923

[7] Aquacel Ag® in the management of partial-thickness burns:: Results of a clinical trial [J].

Caruso, DM ;

Foster, KN ;

Hermans, MHE ;

Rick, C .

JOURNAL OF BURN CARE & REHABILITATION, 2004, 25 (01) :89-97

[8] Microstructure, corrosion properties and bio-compatibility of calcium zinc phosphate coating on pure iron for biomedical application [J].

Chen, Haiyan ;

Zhang, Erlin ;

Yang, Ke .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2014, 34 :201-206

[9] A novel nanocomposite for bone tissue engineering based on chitosan-silk sericin/hydroxyapatite: biomimetic synthesis and its cytocompatibility [J].

Chen, Li ;

Hu, Jingxiao ;

Ran, Jiabing ;

Shen, Xinyu ;

Tong, Hua .

RSC ADVANCES, 2015, 5 (69) :56410-56422

[10] Chain length dependence of antimicrobial peptide-fatty acid conjugate activity [J].

Chu-Kung, Alexander F. ;

Nguyen, Rose ;

Bozzelli, Kristen N. ;

Tirrell, Matthew .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2010, 345 (02) :160-167

← 1 2 3 4 5 →