Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material

被引：71

作者：

Karahaliloglu, Zeynep ^{[1
,2
]}

Kilicay, Ebru ^{[3
]}

Denkbas, Emir Baki ^{[4
]}

机构：

[1] Aksaray Univ, Fac Sci, Aksaray, Turkey

[2] Arts Biol Dept, Aksaray, Turkey

[3] Bulent Ecevit Univ, Zonguldak Vocat High Sch, Zonguldak, Turkey

[4] Hacettepe Univ, Biochem Div, Dept Chem, Ankara, Turkey

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 06期

关键词：

Chitosan; lauric acid; silk sericin; wound dressing; zinc oxide nanoparticles; IN-VITRO; NANOCOMPOSITE; MANAGEMENT; MEMBRANES; PROTEIN; CHITIN;

D O I：

10.1080/21691401.2016.1203796

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Antimicrobial mixed dressings have traditionally been used to minimize bacterial infection of burns and other wounds. This study presents the advancement of biocompatible chitosan/silk sericin (CHT/SS) scaffolds combined with lauric acid (LA) and zinc oxide nanoparticles (nZnO) for the successful wound dressing applications. Antibacterial assay results showed that the diameters of the inhibition zone increased from 2 +/- 0.4 to 7 +/- 0.1mm for Escherichia coli, as well as from 2.5 +/- 0.2 to 6 +/- 0.4mm for Staphylococcus aureus while CHTS/SS/100nZnO compared to CHT/SS/0.01LA. The results not only showed excellent inhibition against Gram-positive and Gram-negative bacterial growth but also revealed improved proliferation and extended viability for HaCaT cells.

引用

页码：1172 / 1185

页数：14

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