Control Systems Technology in the Advanced Manufacturing of Biologic Drugs

被引：0

作者：

Lulu, Amos E. ^{[1
]}

Paulson, Joel A. ^{[1
]}

Mozdzierz, Nicholas J. ^{[1
]}

Stockdale, Alan ^{[1
]}

Versypt, Ashlee N. Ford ^{[2
]}

Love, Kerry R. ^{[1
]}

Love, J. Christopher ^{[1
]}

Braatz, Richard D. ^{[1
]}

机构：

[1] MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] Oklahoma State Univ, Stillwater, OK 74078 USA

来源：

2015 IEEE CONFERENCE ON CONTROL AND APPLICATIONS (CCA 2015) | 2015年

关键词：

ELECTROLYTE-SOLUTIONS; ANTIBODY-PRODUCTION; CELL-CULTURE; PROTEIN; MODEL; SIMULATION; OPTIMIZATION; METABOLISM; TRANSPORT; DESIGN;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

The paper focuses on systems engineering challenges for biomanufacturing, as exemplified by the Integrated and Scalable Cyto-Technology (InSCyT) bio-manufacturing platform under the Defense Advanced Research Projects Agency (DARPA) Biologically-derived Medicines on Demand (Bio-MOD) program. One goal of the project is to apply modeling and simulation techniques to the design, control, and optimization of biomanufacturing operations. In this paper, we present models and control strategies for the unit operations within the InSCyT platform, including a perfusion bioreactor, several packed bed and membrane chromatography steps, and a conductivity-and pH-controlled buffer mixing unit.

引用

页码：1505 / 1515

页数：11

共 49 条

[1] Aggarwal SaurabhRob., 2014, Nature, V201, P4
[2] Computation of electrical conductivity of multicomponent aqueous systems in wide concentration and temperature ranges
Anderko, A
Lencka, MM
[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1997, 36 (05) : 1932 - 1943
[3] Electrolyte solutions: from thermodynamic and transport property models to the simulation of industrial processes
Anderko, A
Wang, PM
Rafal, M
[J]. FLUID PHASE EQUILIBRIA, 2002, 194 : 123 - 142
[4] [Anonymous], 2003, Batch Fermentation: Modeling, Monitoring, and Control
[5] Beck J.V., 1977, Parameter estimation in engineering and science
[6] CONDUCTANCE IN ELECTROLYTE-SOLUTIONS USING THE MEAN SPHERICAL APPROXIMATION
BERNARD, O
KUNZ, W
TURQ, P
BLUM, L
[J]. JOURNAL OF PHYSICAL CHEMISTRY, 1992, 96 (09) : 3833 - 3840
[7] USE OF A STRUCTURED KINETIC-MODEL OF ANTIBODY-SYNTHESIS AND SECRETION FOR OPTIMIZATION OF ANTIBODY-PRODUCTION SYSTEMS .2. TRANSIENT ANALYSIS
BIBILA, TA
FLICKINGER, MC
[J]. BIOTECHNOLOGY AND BIOENGINEERING, 1992, 39 (03) : 262 - 272
[8] EXTENSION AND APPLICATION OF THE PITZER EQUATION FOR VAPOR-LIQUID-EQUILIBRIUM OF AQUEOUS-ELECTROLYTE SYSTEMS WITH MOLECULAR SOLUTES
CHEN, CC
BRITT, HI
BOSTON, JF
EVANS, LB
[J]. AICHE JOURNAL, 1979, 25 (05) : 820 - 831
[9] Chhatre S, 2006, BIOTECHNOL PROGR, V22, P1612, DOI 10.1002/bp0602000
[10] Modelling Approaches for Bio-Manufacturing Operations
Chhatre, Sunil
[J]. MEASUREMENT, MONITORING, MODELLING AND CONTROL OF BIOPROCESSES, 2013, 132 : 85 - 107

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