First case of acute cholestatic hepatitis attributed to oseltamivir in a young girl with AH1N1 influenza

被引：1

作者：

Mastroianni, A. ^{[1
]}

Greco, S. ^{[1
]}

Vangeli, V. ^{[1
]}

Ritacca, R. ^{[2
]}

Mauro, M., V ^{[3
]}

Guadagnino, G. ^{[1
]}

机构：

[1] Annunziata Hosp, Infect & Trop Dis Unit, Cosenza, Italy

[2] Annunziata Hosp, Hosp Pharm, Cosenza, Italy

[3] Annunziata Hosp, Microbiol Unit, Cosenza, Italy

来源：

ANNALI DI IGIENE MEDICINA PREVENTIVA E DI COMUNITA | 2021年 / 33卷 / 03期

关键词：

Influenza; oseltamivir; acute hepatitis; H1N1;

D O I：

10.7416/ai.2021.2427

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Oseltamivir caryboxylase is a potent inhibitor of the enzyme neuramidase of the influenza virus particle and it is active against both influenza A and B viruses. Oseltamivir is indicated for therapy or post-exposure prevention of influenza A and B. Side effects are uncommon and include mild nausea, gastrointestinal upset, dizziness and headache. Despite its widespread use, oseltamivir has not been associated with clinically apparent liver injury. To the best of our knowledge, this is the first case report in the literature linking the development of acute hepatitis to the consumption of oseltamivir in a patient suffering from influenza H1N1 infection.

引用

页码：205 / 208

页数：4

共 10 条

[1]

[Anonymous], 2012, Clinical and Research Information on Drug-Induced Liver Injury Internet-PubMed Internet

[2] The effects of adverse drug reactions on patients' satisfaction: Evidence from publicly available data on Tamiflu (oseltamivir) [J].

Antipov, Evgeny A. ;

Pokryshevskaya, Elena B. .

INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS, 2019, 125 :30-36

[3]

Esper RC, 2010, ANN HEPATOL, V9, P107

[4] Abnormal liver chemistry in patients with influenza A H1N1 [J].

Chen Yingying .

LIVER INTERNATIONAL, 2011, 31 (06) :904-904

[5] The mechanisms of delayed onset type adverse reactions to oseltamivir [J].

Hama, Rokuro .

INFECTIOUS DISEASES, 2016, 48 (09) :651-660

[6] Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments [J].

Jefferson, Tom ;

Jones, Mark ;

Doshi, Peter ;

Spencer, Elizabeth A. ;

Onakpoya, Igho ;

Heneghan, Carl J. .

BMJ-BRITISH MEDICAL JOURNAL, 2014, 348

[7] Acute Liver Failure Associated with Influenza A Virus Infection: an Autopsy Case Report [J].

Nonaka, Keisuke ;

Matsuda, Yoko ;

Kakizaki, Mototsune ;

Takakuma, Shoichiro ;

Hamamatsu, Akihiko ;

Sakashita, Yasuhiro ;

Matsubara, Tomoyasu ;

Murayama, Shigeo ;

Ishiwata, Toshiyuki ;

Yamanaka, Noriko ;

Itabashi, Mitsuyo ;

Takei, Takashi ;

Nakajima, Noriko ;

Hasegawa, Hideki ;

Arai, Tomio .

JAPANESE JOURNAL OF INFECTIOUS DISEASES, 2019, 72 (05) :347-349

[8] Liver involvement during influenza infection: perspective on the 2009 influenza pandemic [J].

Papic, Neven ;

Pangercic, Ana ;

Vargovic, Martina ;

Barsic, Bruno ;

Vince, Adriana ;

Kuzman, Ilija .

INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2012, 6 (03) :e2-e5

[9] Kupffer cell-dependent hepatitis occurs during influenza infection [J].

Polakos, NK ;

Cornejo, JC ;

Murray, DA ;

Wright, KO ;

Treanor, JJ ;

Crispe, IN ;

Topham, DJ ;

Pierce, RH .

AMERICAN JOURNAL OF PATHOLOGY, 2006, 168 (04) :1169-1178

[10] Acute hepatitis and liver failure associated with influenza A infection in children [J].

Whitworth, John R. ;

Mack, Cara L. ;

O'Connor, Judith A. ;

Narkewicz, Michael R. ;

Mengshol, Sarah ;

Sokol, Ronald J. .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2006, 43 (04) :536-538

← 1 →