Making and breaking tolerance

被引：73
作者：
Ohashi, PS
DeFranco, AL
机构：
[1] Univ Hlth Network, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada
[2] Univ Calif San Francisco, George Williams Hooper Fdn, San Francisco, CA 94143 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 06期
关键词：
D O I：
10.1016/S0952-7915(02)00406-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The lymphocyte's decision between tolerance and immunity/autoimmunity is regulated at many levels. Two important parameters in this decision are the maturation state of the antigen presenting cells (APCs) and the amount of self antigen that is detected by the immune system. Maturation of APCs occurs as a consequence of signals received by the innate immune system and may lead to the breakdown of tolerance. Particularly relevant to this process are the Toll-like receptors and mechanisms of cross presentation of self antigens. In addition, genetic alterations in a variety of cell surface receptors, signalling components and regulators of apoptosis/survival can break tolerance and lead to autoimmunity in vivo.
引用
收藏
页码：744 / 759
页数：16
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