Emerging roles of chemokines in prostate cancer

被引：103

作者：

Vindrieux, David ^{[1
,2
]}

Escobar, Pauline ^{[1
,2
]}

Lazennec, Gwendal ^{[1
,2
]}

机构：

[1] INSERM, U844, F-34091 Montpellier, France

[2] Univ Montpellier I, F-34090 Montpellier, France

来源：

关键词：

RECEPTOR CXCR4 EXPRESSION; NF-KAPPA-B; IN-VIVO; ANDROGEN RECEPTOR; INTERLEUKIN-8; EXPRESSION; GENE-EXPRESSION; CELL-ADHESION; BREAST-CANCER; STROMAL CELLS; MIGRATION;

D O I：

10.1677/ERC-09-0109

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer (PCa) represents the second leading cause of death among all cancer types in men in Europe and North America. Among the factors suspected to control PCa, incidence and progression, chemokines, and their receptors are now intensively studied Chemokines are produced by tumor cells and also by the stromal microenvironment, both in the primary tumor site and in distant metastatic locations. The wide and differential distribution of chemokines and their receptors account for the pleiotropic actions of chemokines in PCa, including the modulation of growth, angiogenesis, invasion, metastasis, and hormone escape This review will focus on the roles and the mechanisms of action and regulation of chemokines in the different steps of PCa development and will discuss the novel strategies that are currently envisioned to target chemokines in PCa.

引用

页码：663 / 673

页数：11

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