Estrogenic and Neuroprotective Properties of Scutellarin from Erigeron breviscapus: A Drug against Postmenopausal Symptoms and Alzheimer's Disease

被引：38

作者：

Zhu, Judy T. T. ^{[1
,2
]}

Choi, Roy C. Y. ^{[1
,2
]}

Li, Jun ^{[1
,2
]}

Xie, Heidi Q. H. ^{[1
,2
]}

Bi, Cathy W. C. ^{[1
,2
]}

Cheung, Anna W. H. ^{[1
,2
]}

Dong, Tina T. X. ^{[1
,2
]}

Jiang, Zhi Y. ^{[3
]}

Chen, Ji J. ^{[3
]}

Tsim, Karl W. K. ^{[1
,2
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China

[3] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming, Yunnan, Peoples R China

来源：

PLANTA MEDICA | 2009年 / 75卷 / 14期

关键词：

beta-amyloid; scutellarin; Erigeron breviscapus; Compositae; estrogen; neuroprotection; MOLECULAR-MECHANISMS; REPLACEMENT THERAPY; PC12; CELLS; FLAVONOIDS; CHALLENGES; WOMEN; BETA;

D O I：

10.1055/s-0029-1185776

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Besides the classical hormonal effect, estrogen possesses neuroprotective effects in the brain, which leads to the searching of novel treatments for neurodegenerative diseases such as Alzheimer's disease. Scutellarin is a major flavone derived from Herba Erigerontis, a Chinese medicine derived from Erigeron breviscapus, which has been shown here to possess both estrogenic and neuroprotective properties. Scutellarin showed the estrogenic effects by activating the estrogen responsive elements and phosphorylation of estrogen receptor alpha in cultured MCF-7 cells: the activation was in a dose-dependent manner. On the other hand, scutellarin inhibited the aggregation of beta-amyloid in vitro, and prevented the cell death mediated by beta-amyloid when applied to cultured neuronal PC12 cells. These results therefore suggested that Herba Erigerontis and its component scutellarin might have therapeutic effects against postmenopausal symptoms and Alzheimer's disease.

引用

页码：1489 / 1493

页数：5

共 20 条

[1] From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens [J].