Moxifloxacin/Gatifloxacin-1,2,3-triazole-isatin Hybrids with Hydrogen-Bond Donor and Their In Vitro Anticancer Activity

被引：8

作者：

Chen, Rongxing ^{[1
]}

Zhang, Hao ^{[2
]}

Ma, Tianwei ^{[1
]}

Xue, Huarui ^{[1
]}

Miao, Thong ^{[1
]}

Chen, Liyan ^{[1
]}

Shi, Xiangkui ^{[1
]}

机构：

[1] Xuzhou Women & Childrens Healthcare Hosp, Xuzhou 221009, Jiangsu, Peoples R China

[2] Xuzhou Cent Hosp, Dept Neurosurg, Div 2, Xuzhou 221009, Jiangsu, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2019年 / 56卷 / 09期

关键词：

ISATIN HYBRIDS; QUINOLONE DERIVATIVES; DESIGN;

D O I：

10.1002/jhet.3670

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel moxifloxacin/gatifloxacin-1,2,3-triazole-isatin hybrids (8a-i) were designed, synthesized, and screened for their in vitro anticancer activity in this paper. All of the synthesized hybrids were active against A549 and HepG2 cancer cell lines, whereas the parent drugs moxifloxacin and gatifloxacin were devoid of activity. Among them, hybrid 8i (IC50: 41.1-98.3 mu M) showed considerable activity against A549, HepG2, and MCF-7 cancer cell lines, and it was no inferior to Vorinostat (IC50: 64.32 to >100 mu M) against the three cancer cell lines. Thus, this kind of hybrids has potentiality for discovery of new anticancer candidates for clinical deployment in the control and eradication of cancers.

引用

页码：2691 / 2694

页数：4

共 24 条

[1]

[Anonymous], 2015, Cancer: Key facts

[2]

[Anonymous], 2016, CANC CONTR KNOWL ACT

[3]

[Anonymous], 2018, [88] Grecco, Hernan E., "Pint," 2018. 3., P3

[4] Studies on the antimicrobial properties of N-acylated ciprofloxacins [J].

Cormier, Ryan ;

Burda, Whittney N. ;

Harrington, Lacey ;

Edlinger, Jordan ;

Kodigepalli, Karthik M. ;

Thomas, John ;

Kapolka, Rebecca ;

Roma, Glen ;

Anderson, Burt E. ;

Turos, Edward ;

Shaw, Lindsey N. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (20) :6513-6520

[5] Quinolone derivatives and their activities against methicillin-resistant Staphylococcus aureus (MRSA) [J].

Gao, Chuan ;

Fan, Yi-Lei ;

Zhao, Feng ;

Ren, Qing-Cheng ;

Wu, Xiang ;

Chang, Le ;

Gao, Feng .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 157 :1081-1095

[6] Quinolone hybrids and their anti-cancer activities: An overview [J].

Gao, Feng ;

Zhang, Xia ;

Wang, Tengfei ;

Xiao, Jiaqi .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 165 :59-79

[7] Recent developments of quinolone-based derivatives and their activities against Escherichia coli [J].

Gao, Feng ;

Wang, Peng ;

Yang, Hua ;

Miao, Qing ;

Ma, Long ;

Lu, Guangming .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 157 :1223-1248

[8] Isatin derivatives and their anti-bacterial activities [J].

Guo, Hua .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 164 :678-688

[9] The potential role of tubeimosides in cancer prevention and treatment [J].

Islam, Md Sodrul ;

Wang, Chenying ;

Zheng, Jingyou ;

Paudyal, Narayan ;

Zhu, Yongliang ;

Sun, Hongxiang .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 162 :109-121

[10] Syntheses and Antibacterial Activity of N-Acylated Ciprofloxacin Derivatives Based on the Trimethyl Lock [J].

Ji, Cheng ;

Miller, Patricia A. ;

Miller, Marvin J. .

ACS MEDICINAL CHEMISTRY LETTERS, 2015, 6 (06) :707-710

← 1 2 3 →