Trypanosomu cruzi DHOD structure-based design of 5-halogen and 5-alkyl orotate derivatives

被引：0

作者：

Inaoka, Daniel K. ^{[1
]}

Nayoung, Lee ^{[2
]}

Sakamoto, Kimitoshi ^{[1
]}

Shimizu, Hironari ^{[1
]}

Shiba, Tomoo ^{[3
]}

Kurisu, Genji ^{[3
]}

Nara, Takeshi ^{[4
]}

Aoki, Takashi ^{[4
]}

Inoue, Masayuki ^{[2
]}

Kita, Kiyoshi ^{[1
]}

Harada, Shigeharu ^{[5
]}

机构：

[1] Univ Tokyo, Biomed Chem, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Dept Med Chem, Bunkyo Ku, Tokyo 1130033, Japan

[3] Univ Tokyo, Dept Life Sci, Bunkyo Ku, Tokyo 1130033, Japan

[4] Juntendo Univ, Dept Mol & Cellular Parasitol, Bunkyo Ku, Tokyo 1138421, Japan

[5] Kyoto Inst Technol, Dept Appl Biol, Sakyo Ku, Kyoto 6068585, Japan

来源：

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES | 2008年 / 64卷

关键词：

trypanosoma cruzi; energy metabolism; fumarate reductase; dihydroorotate dehydrogenase; drug design; parasite;

D O I：

10.1107/S0108767308092866

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

P03.04.15

引用

页码：C222 / C222

页数：1