The Roles of Serotonin in Neuropsychiatric Disorders

被引：198

作者：

Pourhamzeh, Mahsa ^{[1
]}

Moravej, Fahimeh Ghasemi ^{[2
]}

Arabi, Mehrnoosh ^{[1
,3
]}

Shahriari, Elahe ^{[4
]}

Mehrabi, Soraya ^{[1
,4
]}

Ward, Richard ^{[5
]}

Ahadi, Reza ^{[6
]}

Joghataei, Mohammad Taghi ^{[1
,6
]}

机构：

[1] Iran Univ Med Sci, Div Neurosci, Cellular & Mol Res Ctr, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Sch Med, Dept Biol & Anat Sci, Tehran, Iran

[3] Kashan Univ Med Sci, Fac Paramed, Dept Radiol & Med Phys, Kashan, Iran

[4] Iran Univ Med Sci, Dept Physiol, Fac Med, Tehran, Iran

[5] Univ Wisconsin Milwaukee, Dept Psychol, Milwaukee, WI USA

[6] Iran Univ Med Sci, Dept Anat, Fac Med, Tehran, Iran

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2022年 / 42卷 / 06期

关键词：

5-HT; SSRI; Mood Disorders; Nervous System Diseases; Serotonin pathway; OBSESSIVE-COMPULSIVE DISORDER; 5-HT4 RECEPTOR AGONIST; REUPTAKE INHIBITORS; DOUBLE-BLIND; FLUOXETINE; NEUROTRANSMISSION; ONDANSETRON; TRANSPORTER; MODULATION; PHYSIOLOGY;

D O I：

10.1007/s10571-021-01064-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The serotonergic system extends throughout the central nervous system (CNS) and the gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a broad spectrum of functions, including mood, cognition, anxiety, learning, memory, reward processing, and sleep. These processes are mediated through 5-HT binding to 5-HT receptors (5-HTRs), are classified into seven distinct groups. Deficits in the serotonergic system can result in various pathological conditions, particularly depression, schizophrenia, mood disorders, and autism. In this review, we outlined the complexity of serotonergic modulation of physiologic and pathologic processes. Moreover, we provided experimental and clinical evidence of 5-HT's involvement in neuropsychiatric disorders and discussed the molecular mechanisms that underlie these illnesses and contribute to the new therapies.

引用

页码：1671 / 1692

页数：22

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