Synthesis of Organofluoro Compounds Using Methyl Perfluoroalk-2-ynoates as Building Blocks

被引：10

作者：

Sun, Xuechun ^{[1
]}

Han, Jing ^{[1
]}

Chen, Jie ^{[1
]}

Zhang, Hui ^{[1
,2
]}

Cao, Weiguo ^{[1
,3
,4
,5
]}

机构：

[1] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China

[2] Shanghai Univ, Instrumental Anal & Res Ctr, Lab Microstruct, Shanghai 200444, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Organ Chem Nat Subst, Shanghai 200032, Peoples R China

[5] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL RECORD | 2016年 / 16卷 / 02期

基金：

中国国家自然科学基金;

关键词：

drug design; fluorine; Michael addition; perfluoroalkyl groups; synthetic methods; C-H ACTIVATION; ONE-POT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; REGIOSELECTIVE SYNTHESIS; CONVENIENT SYNTHESIS; FACILE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; MULTICOMPONENT SYNTHESIS; 3-COMPONENT SYNTHESIS; COUPLING CYCLIZATION;

D O I：

10.1002/tcr.201500258

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review provides an overview of several synthetic applications of methyl perfluoroalk-2-ynoates, leading to convenient preparation of many perfluoroalkylated compounds. The use of these important substrates in the synthesis of various five-, six-, and seven-membered heterocycles, cyclopentadienes, and biphenyls is described, alongside a discussion of the mechanistic aspects of these reactions.

引用

页码：907 / 923

页数：17

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