Solid-phase synthesis of α-alkylserines via phase-transfer catalytic alkylation of polymer-supported 2-phenyl-2-oxazoline-4-carboxylate

被引：2

作者：

Lee, Jihye ^{[1
]}

Ha, Min Woo ^{[1
]}

Kim, Taek-Soo ^{[1
]}

Kim, Mi-Jeong ^{[1
]}

Ku, Jin-Mo ^{[1
]}

Jew, Sang-sup ^{[1
]}

Park, Hyeung-geun ^{[1
]}

Jeong, Byeong-Seon ^{[2
]}

机构：

[1] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[2] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

来源：

TETRAHEDRON | 2009年 / 65卷 / 43期

关键词：

TERT-BUTYL ESTER; AMINO-ACID-DERIVATIVES; HIGHLY ENANTIOSELECTIVE SYNTHESIS; RESIN-BOUND GLYCINE; ASYMMETRIC-SYNTHESIS; CINCHONA ALKALOIDS; AMMONIUM-SALTS; POLY(ETHYLENE GLYCOL); PEPTIDE-SYNTHESIS; MICHAEL ADDITION;

D O I：

10.1016/j.tet.2009.08.052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Described is the development of a new solid-phase synthetic method for alpha-alkylserines in which phase-transfer catalytic alkylation of polymer-supported 2-phenyl-2-oxazoline-4-carboxylate (12) is the key step. The easy preparation of the polymer-supported substrate 12, the high chemical yield (up to 93%), and the mild cleavage conditions could make this method very practical for the synthesis of a-alkylserines. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：8839 / 8843

页数：5

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