Membranous obstruction of the inferior vena cava in a patient with factor V Leiden: Evidence for a post-thrombotic aetiology

被引：17

作者：

Blanshard, C

Dodge, G

Pasi, J

Ormiston, M

Dick, R

Burroughs, AK

机构：

[1] ROYAL FREE HOSP,DEPT LIVER TRANSPLANTAT & HEPATOBILIARY MED,LONDON NW3 2QG,ENGLAND

[2] ROYAL FREE HOSP,DEPT RADIOL,LONDON NW3 2QG,ENGLAND

[3] ROYAL FREE HOSP,DEPT HAEMOPHILIA,LONDON NW3 2QG,ENGLAND

[4] HEMEL HEMPSTEAD GEN HOSP,DEPT SURG,HEMEL HEMPSTEAD,HERTS,ENGLAND

来源：

JOURNAL OF HEPATOLOGY | 1997年 / 26卷 / 03期

关键词：

activated protein C resistance; Budd Chiari syndrome; factor V Leiden; membranous obstruction; thrombosis; vena cava obstruction;

D O I：

10.1016/S0168-8278(97)80442-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Membranous obstruction of the inferior vena cava is a rare cause of hepatic venous outflow obstruction in Caucasians. There has been much debate in the literature about its aetiology. Methods and Results: We describe a Caucasian with hepatic venous outflow obstruction due to an inferior vena cava web, who was found to have hypercoagulability due to factor V Leiden, Following balloon rupture of the membrane and anticoagulation, his symptoms resolved and he has remained well for a year. Conclusions: The age at presentation in this patient, the presence of hypercoagulability and the excellent response to membrane rupture and anticoagulation suggest that in this case the membrane may have been derived from organised thrombus, Balloon rupture of the membrane and anticoagulation appears to be an effective treatment in such cases.

引用

页码：731 / 735

页数：5