Reduced activation to implicit affect induction in euthymic bipolar patients: An fMRI study

被引:100
作者
Malhi, Gin S.
Lagopoulos, Jim
Owen, Adrian M.
Ivanovski, Belinda
Shnier, Ron
Sachdev, Perminder
机构
[1] Prince Wales Med Res Inst, Mayne Clin Res Imaging Ctr, Neurosci Res Grp, Sydney, NSW, Australia
[2] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia
[3] Black Dog Inst, Mood Disorders Unit, Sydney, NSW, Australia
[4] MRC, Cognit & Brain Sci Unit, Cambridge, England
[5] Mayne Grp, Melbourne, Vic, Australia
[6] Prince Wales Hosp, Inst Neuropsychiat, Sydney, NSW, Australia
[7] NISAD, Sydney, NSW, Australia
关键词
fMRI; affect; bipolar disorder; euthymia; mood induction; ANTERIOR CINGULATE CORTEX; CEREBRAL-BLOOD-FLOW; FUNCTIONAL NEUROANATOMY; COGNITIVE GENERATION; PREFRONTAL CORTEX; EPISODIC MEMORY; EMOTIONAL CONNOTATION; FACIAL EXPRESSIONS; RECOGNITION MEMORY; GLUCOSE-METABOLISM;
D O I
10.1016/j.jad.2006.06.005
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To examine whether euthymic bipolar patients engage similar or contrasting brain regions as healthy subjects when responding to implicit affect induction. Methods: The study examined 10 euthymic patients with bipolar I disorder, and 10 age- and gender-matched healthy subjects using event-related functional magnetic resonance imaging (fMRI) while subjects engaged in a modified word-based memory task designed to implicitly evoke negative, positive or no affective change. The activation paradigm involved nominating whether a target word was contained within a previously presented word list using specified response keys. Results: The fMRI task produced significantly greater activation in healthy subjects as compared to patients in response to both negative and positive affect in the anterior and posterior cingulate, medial prefrontal cortex, middle frontal and right parahippocampal gyri. Only negative affect produced significantly greater activation in the postcentral gyrus, inferior parietal lobule, thalamus and putamen and only positive affect achieved the same in the precentral, superior temporal and lingual gyri, precuneus, cuneus, caudate, pons, midbrain and cerebellum. There were no brain regions in which responses were greater in patients as compared to healthy subjects. There were no statistically significant differences between the groups with respect to speed or accuracy. Conclusions: Diminished prefrontal, cingulate, limbic and subcortical neural activity in euthymic bipolar patients as compared to healthy subjects is suggestive of emotional compromise that is independent of cognitive and executive functioning. This finding is of clinical importance and has implications both for the diagnosis and treatment of bipolar disorder. Future studies should aim to replicate these findings and examine the development of bipolar disorder, investigating in particular the effects of medication. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:109 / 122
页数:14
相关论文
共 50 条
  • [41] Is coping well a matter of personality? A study of euthymic unipolar and bipolar patients
    Coulston, Carissa M.
    Bargh, Danielle M.
    Tanious, Michelle
    Cashman, Emma L.
    Tufrey, Kimberly
    Curran, Genevieve
    Kuiper, Sandy
    Morgan, Hugh
    Lampe, Lisa
    Malhi, Gin S.
    JOURNAL OF AFFECTIVE DISORDERS, 2013, 145 (01) : 54 - 61
  • [42] Subjective and physiological emotional response in euthymic bipolar patients: A pilot study
    Lemaire, Mathieu
    Aguillon-Hernandez, Nadia
    Bonnet-Brilhault, Frederique
    Martineau, Joelle
    El-Hage, Wissam
    PSYCHIATRY RESEARCH, 2014, 220 (1-2) : 294 - 301
  • [43] Outcome of cognitive performances in bipolar euthymic patients after a depressive episode: a longitudinal naturalistic study
    Paunescu, Ramona
    Miclutia, Ioana
    ANNALS OF GENERAL PSYCHIATRY, 2015, 14
  • [44] Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study
    Favre, Pauline
    Polosan, Mircea
    Pichat, Cedric
    Bougerol, Thierry
    Baciu, Monica
    PLOS ONE, 2015, 10 (08):
  • [45] Outcome of cognitive performances in bipolar euthymic patients after a depressive episode: a longitudinal naturalistic study
    Ramona Păunescu
    Ioana Micluţia
    Annals of General Psychiatry, 14
  • [46] Restoration of frontal activation during, a treatment with quetiapmie:: an fMRI study of blunted affect in schizophrenia
    Stip, E
    Fahim, C
    Mancini-Marïe, A
    Bentaleb, LA
    Mensour, B
    Mendrek, A
    Beauregard, M
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2005, 29 (01) : 21 - 26
  • [47] Modulation of fronto-limbic activity by the psychoeducation in euthymic bipolar patients. A functional MRI study
    Favre, Pauline
    Baciu, Monica
    Pichat, Cedric
    De Pourtales, Marie-Atea
    Fredembach, Benjamin
    Garcon, Sabrina
    Bougerol, Thierry
    Polosan, Mircea
    PSYCHIATRY RESEARCH-NEUROIMAGING, 2013, 214 (03) : 285 - 295
  • [48] Cognitive Impairment in Euthymic Bipolar Patients - A Cross Sectional Case Control Study
    Talapatra, Devlina
    INDIAN JOURNAL OF PSYCHIATRY, 2016, 58 (05) : S67 - S67
  • [49] Neurocognitive impairment of euthymic bipolar patients in a Chilean outpatient clinic: a cross-sectional pilot study
    Sanchez, R. F.
    Flores, P.
    Aguirre, J.
    Padilla, O.
    Cumsille, P.
    BIPOLAR DISORDERS, 2012, 14 : 121 - 121
  • [50] A 1HMRS study of the anterior cingulate gyrus in euthymic bipolar patients
    Amaral, Jose Antonio de M. S.
    Tamada, Renata S.
    Issler, Cilly K.
    Caetano, Sheila C.
    Cerri, Giovanni G.
    de Castro, Claudio C.
    Lafer, Beny
    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2006, 21 (04) : 215 - 220