Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation

被引：0
作者：
Cappello, F [1 ]
Bellafiore, M [1 ]
Palma, A [1 ]
Bucchieri, F [1 ]
机构：
[1] Univ Palermo, Dipartimento Med Sperimentale, Sez Anat Umana, I-90133 Palermo, Italy
来源：
EUROPEAN JOURNAL OF HISTOCHEMISTRY | 2002年 / 46卷 / 03期
关键词：
apoptosis; p53; Fas; FasL; tumorigenesis; gene therapy;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The transcription factor p53 and the cytokine receptor FasL are two of the most famous regulators of cell life, and their alterations can cause a large number of pathologies, including cancer. In this review, we focused on how they can determine defective apoptosis, one of the causes of tumorigenesis and tumor progression. The importance of this knowledge lies in the new perspectives that gene therapy can offer to cure cancer.
引用
收藏
页码：199 / 208
页数：10
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