No association between the Ser9Gly polymorphism of the dopamine D3 receptor gene and schizophrenia in a Spanish sample

被引：10
作者：
Vaquero Lorenzo, C.
Baca-Garcia, E.
Diaz Hernandez, M.
Botillo Martin, C.
Perez-Rodriguez, M. M.
Saiz-Gonzalez, M. D.
Fernandez, P.
Quintero Gutierrez, F. J.
Saiz-Ruiz, J.
Fernandez Piqueras, J.
de Rivera, J. L. Gonzalez
de Leon, J.
机构：
[1] Univ Autonoma Madrid, Madrid, Spain
[2] Fdn Jimenes Diaz Univ Hosp, Dept Psychiat, Madrid, Spain
[3] Ramon & Cajal Univ Hosp, Dept Psychiat, Madrid, Spain
[4] Eastern State Hosp, Mental Hlth Res Ctr, Lexington, KY USA
来源：
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2007年 / 144B卷 / 03期
关键词：
DRD3; gene; association study; genetics; schizophrenia;
D O I：
10.1002/ajmg.b.30331
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
This study aims to further evaluate the controversial association between the Ser9Gly polymorphism in codon 9 of the D3 dopamine receptor gene (DRD3) and schizophrenia in psychiatric inpatients acutely hospitalized in two general hospitals in Madrid, Spain. The Ser9Gly polymorphism. of the DRD3 was examined in 178 schizophrenic patients, 286 patients with other psychiatric diagnoses, and 132 controls recruited. Genotype frequencies were in Hardy-Weinberg equilibrium. No association was found between schizophrenia and the Ser9Gly polymorphism of the D3 dopamine receptor gene. (c) 2006 Wiley-Liss, Inc.
引用
收藏
页码：344 / 346
页数：3
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