The effect of drop vehicle on the efficacy and side effects of topical glaucoma therapy: a review

被引：76

作者：

Yee, Richard W. ^{[1
]}

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Ophthalmol, Hermann Eye Ctr, Houston, TX 77030 USA

来源：

CURRENT OPINION IN OPHTHALMOLOGY | 2007年 / 18卷 / 02期

关键词：

alpha agonist; benzalkonium chloride; beta blocker; carbonic anhydrase inhibitor; glaucoma; preservative; prostaglandin analogue (PGA);

D O I：

10.1097/ICU.0b013e328089f1c8

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose of review Topically applied medications are frequently used in ophthalmology to treat acute and chronic conditions, and are considered to be safer than their systemically applied counterparts, due to the reduced rate of systemic side effects. Recent findings Many experimental and clinical studies have reported that the long-term use of topical medications in chronic ophthalmic conditions, such as glaucoma, may adversely affect the ocular surface. Preservatives play a pivotal role in almost all multidose ophthalmic preparations, inhibiting microbial growth and preserving the active drug. Consequently, preservatives are partially responsible for ocular side effects, although the exact mechanism of these side effects is not known. Summary The role of preservatives in the efficacy and side effects of antiglaucoma drugs is reviewed. The recent advances in preservative technologies and their role in decreasing the side effects associated with antiglaucoma drugs are also discussed.

引用

页码：134 / 139

页数：6

共 43 条

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Yee, Richard W. ;

Norcom, Evan G. ;

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ADVANCES IN THERAPY, 2006, 23 (04) :511-518

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