Recent progress in transdermal sonophoresis

被引：44
作者：
Ita, Kevin [1 ]
机构：
[1] Touro Univ, Coll Pharm, Vallejo, CA 94592 USA
来源：
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2017年 / 22卷 / 04期
关键词：
Acoustic streaming; cavitation; drug delivery; sonophoresis; transdermal; LOW-FREQUENCY SONOPHORESIS; SKIN PENETRATION ENHANCERS; MOLECULAR-WEIGHT HEPARIN; DRUG-DELIVERY; ACOUSTIC CAVITATION; DUAL-FREQUENCY; BUBBLE-GROWTH; ULTRASOUND; TRANSPORT; MICRONEEDLES;
D O I：
10.3109/10837450.2015.1116566
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Transdermal drug administration has a number of advantages that cannot be leveraged for therapeutic benefits because of the robust barrier provided by the stratum corneum. One of the promising techniques for circumventing the stratum corneum is sonophoresis - the use of ultrasound for facilitating transdermal drug delivery. In this review, the mechanisms underlying sonophoresis and the utilization of the technique for transdermal delivery are discussed. The challenges of this mode of drug administration have also been highlighted and insight from a number of toxicological studies is described.
引用
收藏
页码：458 / 466
页数：9
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