Mechanism of seizure-induced retrograde amnesia

被引：19

作者：

Naik, Aijaz Ahmad ^{[1
]}

Sun, Huayu ^{[2
]}

Williams, Cedric L. ^{[4
]}

Weller, Daniel S. ^{[5
]}

Zhu, J. Julius ^{[6
]}

Kapur, Jaideep ^{[1
,2
,3
]}

机构：

[1] Univ Virginia, Dept Neurol, Charlottesville, VA 22903 USA

[2] Univ Virginia, UVA Brain Inst, Charlottesville, VA USA

[3] Univ Virginia, Dept Neurosci, Charlottesville, VA USA

[4] Univ Virginia, Dept Psychol, Gilmer Hall, Charlottesville, VA 22903 USA

[5] Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22903 USA

[6] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA

来源：

PROGRESS IN NEUROBIOLOGY | 2021年 / 200卷

关键词：

Seizure; TRAP; T maze; EPSC; Engram; LTP; LONG-TERM POTENTIATION; DENTATE GYRUS; ELECTROCONVULSIVE-THERAPY; LASTING POTENTIATION; PROXIMODISTAL AXIS; ENTORHINAL CORTEX; PROTEIN-SYNTHESIS; WORKING-MEMORY; REMOTE MEMORY; ENGRAM CELLS;

D O I：

10.1016/j.pneurobio.2020.101984

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Seizures cause retrograde amnesia, but underlying mechanisms are poorly understood. We tested whether seizure activated neuronal circuits overlap with spatial memory engram and whether seizures saturate LTP in engram cells. A seizure caused retrograde amnesia for spatial memory task. Spatial learning and a seizure caused cFos expression and synaptic plasticity overlapping set of neurons in the CA1 of the hippocampus. Recordings from learning-labeled CA1 pyramidal neurons showed potentiated synapses. Seizure-tagged neurons were also more excitable with larger rectifying excitatory postsynaptic currents than surrounding unlabeled neurons. These neurons had enlarged dendritic spines and saturated LTP. A seizure immediately after learning, reset the memory engram. Seizures cause retrograde amnesia through shared ensembles and mechanisms.

引用

页数：14

共 92 条

[1] Molecular Mechanisms of the Memory Trace [J].

Asok, Arun ;

Leroy, Felix ;

Rayman, Joseph B. ;

Kandel, Eric R. .

TRENDS IN NEUROSCIENCES, 2019, 42 (01) :14-22

[2]

Baker J, 2017, STUD NEUROSCI, P401, DOI 10.1007/978-3-319-45066-7_24

[3]

BARNES CA, 1994, J NEUROSCI, V14, P5793

[4] The neurobiology of cognitive disorders in temporal lobe epilepsy [J].

Bell, Brian ;

Lin, Jack J. ;

Seidenberg, Michael ;

Hermann, Bruce .

NATURE REVIEWS NEUROLOGY, 2011, 7 (03) :154-164

[5] LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF ANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH [J].

BLISS, TVP ;

LOMO, T .

JOURNAL OF PHYSIOLOGY-LONDON, 1973, 232 (02) :331-356

[6] A new clinico-pathological classification system for mesial temporal sclerosis [J].

Bluemcke, Ingmar ;

Pauli, Elisabeth ;

Clusmann, Hans ;

Schramm, Johannes ;

Becker, Albert ;

Elger, Christian ;

Merschhemke, Martin ;

Meencke, Heinz-Joachim ;

Lehmann, Thomas ;

von Deimling, Andreas ;

Scheiwe, Christian ;

Zentner, Josef ;

Volk, Benedikt ;

Romstoeck, Johann ;

Stefan, Hermann ;

Hildebrandt, Michelle .

ACTA NEUROPATHOLOGICA, 2007, 113 (03) :235-244

[7] INWARD RECTIFICATION OF BOTH AMPA AND KAINATE SUBTYPE GLUTAMATE RECEPTORS GENERATED BY POLYAMINE-MEDIATED ION-CHANNEL BLOCK [J].

BOWIE, D ;

MAYER, ML .

NEURON, 1995, 15 (02) :453-462

[8] Self-assessed remission rates after electroconvulsive therapy of depressive disorders [J].

Brus, O. ;

Cao, Y. ;

Gustafsson, E. ;

Hulten, M. ;

Landen, M. ;

Lundberg, J. ;

Nordanskog, P. ;

Nordenskjold, A. .

EUROPEAN PSYCHIATRY, 2017, 45 :154-160

[9] Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory [J].

Bui, Anh D. ;

Nguyen, Theresa M. ;

Limouse, Charles ;

Kim, Hannah K. ;

Szabo, Gergely G. ;

Felong, Sylwia ;

Maroso, Mattia ;

Soltesz, Ivan .

SCIENCE, 2018, 359 (6377) :787-790

[10] Recent insights into the impairment of memory in epilepsy: transient epileptic amnesia, accelerated long-term forgetting and remote memory impairment [J].

Butler, C. R. ;

Zeman, A. Z. .

BRAIN, 2008, 131 :2243-2263

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