Mesoporous organosilica nanoparticles with large radial pores via an assembly-reconstruction process in bi-phase

被引：30

作者：

Dang, Meng ^{[1
,2
]}

Li, Wei ^{[3
]}

Zheng, Yuanyi ^{[4
]}

Su, Xiaodan ^{[1
,2
]}

Ma, Xiaobo ^{[1
,2
]}

Zhang, Yunlei ^{[2
,5
]}

Ni, Qianqian ^{[5
]}

Tao, Jun ^{[1
,2
]}

Zhang, Junjie ^{[1
,2
]}

Lu, Guangming ^{[5
]}

Teng, Zhaogang ^{[1
,2
,5
,6
]}

Wang, Lianhui ^{[1
,2
]}

机构：

[1] Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China

[2] Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China

[3] Fudan Univ, Adv Mat Lab, Shanghai Key Lab Mol Catalysis & Innovat Mat, Dept Chem, Shanghai 200433, Peoples R China

[4] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China

[5] Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, Nanjing 210002, Jiangsu, Peoples R China

[6] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Jiangsu, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 14期

基金：

中国国家自然科学基金;

关键词：

TRANSFORMATION APPROACH; SILICA NANOPARTICLES; FACILE SYNTHESIS; HOLLOW SPHERES; DRUG-DELIVERY; GENE DELIVERY; SHELL; CANCER; GROWTH; MESOCHANNELS;

D O I：

10.1039/c6tb03327j

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Mesoporous organosilica nanoparticles (MONs) have attracted increasing interest for guest molecule delivery. In this work, we prepared MONs with radially oriented large pores for the first time in a water-ethanol/n-hexane biphasic reaction system. The MONs possess ethane-incorporated organosilica frameworks, large radial pores with openings of 17-78 nm, a high surface area (1219 cm(2) g(-1)), a large pore volume (2.2 cm(3) g(-1)), tunable diameters (124-287 nm), and excellent biocompatibility. We reveal that the formation of large pore MONs in the biphasic reaction system undergoes a surfactant-directed self-assembly following mesostructure reconstruction, providing a new mechanism for the preparation of large mesoporous nanoparticles. Also, the effects of the reaction parameters including temperature and the stirring rate on the pore size are systemically investigated. Furthermore, large pore MONs were loaded with bovine serum albumin (BSA) and small interference RNA (siRNA), which exhibit high protein loading and siRNA delivery capabilities, suggesting the potential of the MONs for biomedical applications.

引用

页码：2625 / 2634

页数：10