Validation of Radiation Volume by Analysis of Recurrence Pattern in Breast-conserving Treatment for Early Breast Cancer

被引:2
作者
Shim, Su Jung [1 ]
Kim, Yong Bae [1 ]
Keum, Ki Chang [1 ]
Lee, Ik Jae [1 ]
Lee, Hy De [2 ]
Suh, Chang-Ok [1 ]
机构
[1] Yonsei Univ, Coll Med, Dept Radiat Oncol, Yonsei Canc Ctr, Seoul 120752, South Korea
[2] Yonsei Univ, Coll Med, Dept Surg, Yonsei Canc Ctr, Seoul 120752, South Korea
关键词
Breast conserving surgery; Radiotherapy; Recurrence; COMPARING TOTAL MASTECTOMY; REGIONAL NODAL FAILURE; POSITIVE LYMPH-NODES; RANDOMIZED-TRIAL; STAGE-I; CONSERVATIVE SURGERY; FOLLOW-UP; POSTOPERATIVE RADIOTHERAPY; PREMENOPAUSAL WOMEN; IRRADIATION;
D O I
10.4048/jbc.2009.12.4.257
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To assess the appropriateness of radiotherapy volume for patients receiving breast-conserving treatment (BGT) through analysis of recurrence pattern and factors affecting recurrence. Methods: From 1991 to 1996, 362 patients who received BCT were retrospectively evaluated. The radiation volume was the involved breast alone in the patents with less than 4 positive axillary lymph nodes (LNs), and breast and supraclavicular fossa in patients with 4 or more positive axillary LNs. The median follow-up period was 123 months (range, 3-169 months). Results: Ten-year overall, disease-free, local recurrence-free, and regional recurrence-free survival rates were 86.2%, 82.2%, 95.9%, and 95.2%, respectively. Among 310 patients receiving radiotherapy on the breast alone, 15 (4.8%) had regional recurrence. In particular, patients with inner quadrant lesions had high regional recurrence rates (11/98, 11.2%) (p<0.001). Conclusion: These low local recurrence rates may reveal that the current radiotherapy technique was successful. However, in cases of inner quadrant lesions, there were a considerable number of regional recurrences, even in NO cases. This may suggest a potential role for irradiation on regional LNs in this group.
引用
收藏
页码:257 / 264
页数:8
相关论文
共 31 条
  • [21] The potential impact of treatment variations on the results of radiotherapy of the internal mammary lymph node chain: A quality-assurance report on the dummy run of EORTC phase III randomized trial 22922/10925 in stage I-III breast cancer
    Poortmans, PMP
    Venselaar, JLM
    Struikmans, H
    Hurkmans, CW
    Davis, JB
    Huyskens, D
    van Tienhoven, G
    Vlaun, V
    Lagendijk, JJW
    Mijnheer, BJ
    De Winter, KA
    Van der Hulst, MH
    Van den Bogaert, WFC
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 49 (05): : 1399 - 1408
  • [22] Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer
    Ragaz, J
    Jackson, SM
    Le, N
    Plenderleith, IH
    Spinelli, JJ
    Basco, VE
    Wilson, KS
    Knowling, MA
    Coppin, CML
    Paradis, M
    Coldman, AJ
    Olivotto, IA
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (14) : 956 - 962
  • [23] BREAST RELAPSE FOLLOWING PRIMARY RADIATION-THERAPY FOR EARLY BREAST-CANCER .1. CLASSIFICATION, FREQUENCY AND SALVAGE
    RECHT, A
    SILVER, B
    SCHNITT, S
    CONNOLLY, J
    HELLMAN, S
    HARRIS, JR
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1985, 11 (07): : 1271 - 1276
  • [24] REGIONAL NODAL FAILURE AFTER CONSERVATIVE SURGERY AND RADIOTHERAPY FOR EARLY-STAGE BREAST-CARCINOMA
    RECHT, A
    PIERCE, SM
    ABNER, A
    VICINI, F
    OSTEEN, RT
    LOVE, SM
    SILVER, B
    HARRIS, JR
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (06) : 988 - 996
  • [25] Clinical trials update of the European Organization for Research and Treatment of Cancer Breast Cancer Group
    Rutgers, EJT
    Meijnen, P
    Bonnefoi, H
    [J]. BREAST CANCER RESEARCH, 2004, 6 (04) : 165 - 169
  • [26] Fifteen-year results of breast-conserving surgery and definitive irradiation for stage I and II breast carcinoma: The University of Pennsylvania experience
    Santiago, RJ
    Wu, L
    Harris, E
    Fox, K
    Schultz, D
    Glick, J
    Solin, LJ
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 58 (01): : 233 - 240
  • [27] The role of irradiation of the internal mammary lymph nodes in high-risk stage II to IIIA breast cancer patients after high-dose chemotherapy: A prospective sequential nonrandomized study
    Stemmer, SM
    Rizel, S
    Hardan, I
    Adamo, A
    Neumann, A
    Goffman, J
    Brenner, HJ
    Pfeffer, MR
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (14) : 2713 - 2718
  • [28] SUH CO, 1997, J KOREAN SOC THER RA, V5, P331
  • [29] SUH CO, 1994, J KOREAN SOC THER RA, V12, P337
  • [30] BREAST CONSERVATION IS THE TREATMENT OF CHOICE IN SMALL BREAST-CANCER - LONG-TERM RESULTS OF A RANDOMIZED TRIAL
    VERONESI, U
    BANFI, A
    SALVADORI, B
    LUINI, A
    SACCOZZI, R
    ZUCALI, R
    MARUBINI, E
    DELVECCHIO, M
    BORACCHI, P
    MARCHINI, S
    MERSON, M
    SACCHINI, V
    RIBOLDI, G
    SANTORO, G
    [J]. EUROPEAN JOURNAL OF CANCER, 1990, 26 (06) : 668 - 670