Growth curves and survival characteristics of the animals used in the biomarkers of aging program

被引：544

作者：

Turturro, A

Witt, WW

Lewis, S

Hass, BS

Lipman, RD

Hart, RW

机构：

[1] US FDA, Natl Ctr Toxicol Res, Div Biometry & Risk Assessment, Jefferson, AR 72079 USA

[2] US FDA, Natl Ctr Toxicol Res, Div Vet Serv, Jefferson, AR 72079 USA

[3] US FDA, Natl Ctr Toxicol Res, Bionet Corp, Jefferson, AR 72079 USA

[4] US FDA, Natl Ctr Toxicol Res, Off Director, Jefferson, AR 72079 USA

[5] Tufts Univ, USDA, Human Nutr Res Ctr, Boston, MA 02111 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 1999年 / 54卷 / 11期

关键词：

D O I：

10.1093/gerona/54.11.B492

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The collaborative Interagency Agreement between the National Center for Toxicological Research (NCTR) and the National Institute on Aging (NIA) was aimed at identifying and validating a panel of biomarkers of aging bl rodents ill order to rapidly test the efficacy and safety of interventions designed to slow aging. Another aim was to provide a basis for developing biomarkers of aging in humans, using the assumption that biomarkers that were useful across different genotypes and species were sensitive to fundamental processes that would extrapolate to humans. Caloric restriction (CR), the only intervention that consistently extends both mean and maximal life span in a variety of species, was used to provide a model with extended life span. C57B1/6NNia, DBA/2JNia, B6D2F1, and B6C3F1 mice and Brown Norway (BN/RijNia), Fischer (F344/NNia) and Fischer x Brown Norway hybrid (F344 x BN F1) rats were bred and maintained on study. NCTR generated data from over 60,000 individually housed animals of the seven different genotypes and both sexes, approximately half ad libitum (AL) fed, the remainder CR. Approximately half the animals half shipped to offsite NIA investigators internationally with the majority of the remainder maintained at NCTR until they died. The collaboration supplied a choice of healthy, long-lived rodent models to investigators, while allowing for the development of some of the most definitive information on life spall, food consumption, and growth characteristics in these genotypes under diverse feeding paradigms.

引用

页码：B492 / B501

页数：10

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