Detection of colorectal cancer using 18F-FLT PET: comparison with 18F-FDG PET

被引：24
作者：
Yamamoto, Yuka [1 ]
Kameyama, Reiko [1 ]
Izuishi, Kunihiko [2 ]
Takebayashi, Ryusuke [2 ]
Hagiike, Masanobu [2 ]
Asakura, Masato [3 ]
Haba, Reiji [4 ]
Nishiyama, Yoshihiro [1 ]
机构：
[1] Kagawa Univ, Fac Med, Dept Radiol, Miki, Kagawa 7610793, Japan
[2] Kagawa Univ, Dept Surg Gastroenterol, Miki, Kagawa 7610793, Japan
[3] Kagawa Univ, Dept Pharm, Miki, Kagawa 7610793, Japan
[4] Kagawa Univ, Dept Diagnost Pathol, Miki, Kagawa 7610793, Japan
来源：
NUCLEAR MEDICINE COMMUNICATIONS | 2009年 / 30卷 / 11期
关键词：
colorectal cancer; F-18-fluoro-D-glucose; F-18-fluorothymidine; Ki-67; positron emission tomography; POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO; IMAGING PROLIFERATION; THORACIC TUMORS; LUNG-TUMORS; VALIDATION; THYMIDINE; IMPACT;
D O I：
10.1097/MNM.0b013e328330294d
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Objective We investigated the feasibility of 3'-deoxy-3'-F-18-fIuorothymidine (FLT) positron emission tomography (PET) for the detection of colorectal cancer, in comparison with 2-deoxy-2-F-18-fluoro-D-glucose (FDG) PET, and investigated correlation of the two radiotracers used with proliferative activity as indicated by Ki-67 index. Methods A total of 26 patients with newly diagnosed colorectal cancer were examined with FLT PET and FDG PET. Tumor lesions were identified as areas of focally increased uptake, exceeding that of surrounding normal tissue. For semiquantitative analysis, the maximal standardized uptake value (SUV) was calculated. Results In all 26 patients, colorectal cancers were detected by both FLT PET and FDG PET. The mean (+/- SD) values of FLT SUV in colon cancer (5.4 +/- 2.4) and in rectal cancer (5.6 +/- 1.3) were significantly lower than the corresponding values of FDG SUV (12.4 +/- 6.3 and 12.5 +/- 4.7, respectively) (P < 0.003). There was no significant correlation between Ki-67 index and either FLT SUV or FDG SUV. Conclusion Although uptake of FLT was found to be significantly lower than that of FDG, both FLT PET and FDG PET were able to detect colorectal cancers in all 26 patients. Neither of the two radiotracers used was correlated with proliferative activity. Nucl Med Commun 30:841-845 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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页码：841 / 845
页数：5
相关论文
共 24 条
[1]  
Barthel H, 2003, CANCER RES, V63, P3791
[2]  
Buck AK, 2003, J NUCL MED, V44, P1426
[3]   Clinical relevance of imaging proliferative activity in lung nodules [J].
Buck, AK ;
Hetzel, M ;
Schirrmeister, H ;
Halter, G ;
Möller, P ;
Kratochwil, C ;
Wahl, A ;
Glatting, G ;
Mottaghy, FM ;
Mattfeldt, T ;
Neumaier, B ;
Reske, SN .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2005, 32 (05) :525-533
[4]  
Cobben DCP, 2004, J NUCL MED, V45, P226
[5]   P53 expression, DNA ploidy and S-phase cell fraction in operable locally advanced non-small-cell lung cancer [J].
Costa, A ;
Silvestrini, R ;
Mochen, C ;
Lequaglie, C ;
Boracchi, P ;
Faranda, A ;
Vessecchia, G ;
Ravasi, G .
BRITISH JOURNAL OF CANCER, 1996, 73 (07) :914-919
[6]   [18F]FLT PET for diagnosis and staging of thoracic tumours [J].
Dittmann, H ;
Dohmen, BM ;
Paulsen, F ;
Eichhorn, K ;
Eschmann, SM ;
Horger, M ;
Wehrmann, M ;
Machulla, HJ ;
Bares, R .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2003, 30 (10) :1407-1412
[7]   In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography [J].
Francis, DL ;
Freeman, A ;
Visvikis, D ;
Costa, DC ;
Luthra, SK ;
Novelli, M ;
Taylor, I ;
Ell, PJ .
GUT, 2003, 52 (11) :1602-1606
[8]   Potential impact of [18F]3′-deoxy-3′-fluorothymidine versus [18F]fluoro-2-deoxy--glucose in positron emission tomography for colorectal cancer [J].
Francis, DL ;
Visvikis, D ;
Costa, DC ;
Arulampalam, THA ;
Townsend, C ;
Luthra, SK ;
Taylor, I ;
Ell, PJ .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2003, 30 (07) :988-994
[9]  
Greene FL., 2002, AJCC CANC STAGING HD, V6th
[10]  
Kalff V, 2002, J NUCL MED, V43, P492
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