Circular RNA Regulation of Myogenesis

被引：72

作者：

Zhang, Pengpeng ^{[1
]}

Chao, Zhe ^{[2
]}

Zhang, Rui ^{[1
]}

Ding, Ruoqi ^{[1
]}

Wang, Yaling ^{[1
]}

Wu, Wei ^{[1
]}

Han, Qiu ^{[1
]}

Li, Cencen ^{[1
]}

Xu, Haixia ^{[1
]}

Wang, Lei ^{[1
]}

Xu, Yongjie ^{[1
]}

机构：

[1] Xinyang Normal Univ, Coll Life Sci, Dept Biotechnol, Xinyang 464000, Peoples R China

[2] Hainan Acad Agr Sci, Inst Anim Sci & Vet Med, Haikou 571100, Hainan, Peoples R China

来源：

CELLS | 2019年 / 8卷 / 08期

基金：

中国国家自然科学基金;

关键词：

circular RNA; circRNA; skeletal muscle; myogenesis; PROMOTES DIFFERENTIATION; CIRCRNA BIOGENESIS; STEM-CELLS; MUSCLE; TRANSCRIPTION; PROLIFERATION; MYOBLASTS; MICRORNAS; ABUNDANT; ORGANS;

D O I：

10.3390/cells8080885

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Circular RNA (circRNA) is a novel class of non-coding RNA generated by pre-mRNA back splicing, which is characterized by a closed-loop structure. Although circRNAs were firstly reported decades ago, their regulatory roles have not been discovered until recently. In this review, we discussed the putative biogenesis pathways and regulatory functions of circRNAs. Recent studies showed that circRNAs are abundant in skeletal muscle tissue, and their expression levels are regulated during muscle development and aging. We, thus, characterized the expression profile of circRNAs in skeletal muscle and discussed regulatory functions and mechanism-of-action of specific circRNAs in myogenesis. The future investigation into the roles of circRNAs in both physiological and pathological conditions may provide novel insights in skeletal muscle development and provide new therapeutic strategies for muscular diseases.

引用

页数：13

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