"Nodule in Nodule" on Thyroid Ultrasonography: Possibility of Follicular Carcinoma Transformed from Benign Thyroid Tumor

被引：8

作者：

Kobayashi, Kaoru ^{[1
]}

Ota, Hisashi ^{[1
]}

Hirokawa, Mitsuyoshi ^{[1
]}

Yabuta, Tomonori ^{[1
]}

Fukushima, Mitsuhiro ^{[1
]}

Masuoka, Hiroo ^{[1
]}

Higashiyama, Takuya ^{[1
]}

Kihara, Minoru ^{[1
]}

Ito, Yasuhiro ^{[1
]}

Miya, Akihiro ^{[1
]}

Miyauchi, Akira ^{[1
]}

机构：

[1] Kuma Hosp, Kobe, Hyogo, Japan

来源：

EUROPEAN THYROID JOURNAL | 2017年 / 6卷 / 02期

关键词：

Thyroid; Nodule in nodule; Diagnosis; Follicular carcinoma; Ultrasonography; KI-67; DIAGNOSIS; MARKERS;

D O I：

10.1159/000452971

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: It is generally considered impossible to differentiate follicular carcinomas from follicular adenomas by means of ultrasonography or cytology before surgery. Therefore, follicular carcinoma is histopathologically diagnosed by verifying capsular and/or vascular invasion after surgery. However, ultrasonography may play an important role in diagnosing follicular carcinoma preoperatively in a small number of cases. Case Description: Four cases of follicular carci-noma or follicular neoplasm that transformed from a benign thyroid tumor and demonstrated a "nodule in nodule" appearance on ultrasonography are presented in this report. Characteristic ultrasound features of such patients are: (1) a "nodule in nodule" appearance, (2) a well-defined boundary line between the nodules, and (3) separate distribution of blood signals within each nodule. Conclusion: A small number of patients with follicular carcinomas or follicular neoplasms may present with a "nodule in nodule" appearance on ultrasonography. It was suggested a long time ago that follicular carcinomas may develop from benign thyroid tumors. The fact that follicular carcinomas appear within benign tumors may be evidence of thyroid tumorigenesis. (C) 2016 European Thyroid Association Published by S. Karger AG, Basel

引用

页码：101 / 107

页数：7

共 16 条

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