Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells

被引：57

作者：

Baaklini, Charbel S. ^{[1
]}

Rawji, Khalil S. ^{[2
]}

Duncan, Greg J. ^{[3
]}

Ho, Madelene F. S. ^{[1
]}

Plemel, Jason R. ^{[1
]}

机构：

[1] Univ Alberta, Fac Med & Dent, Neurosci & Mental Hlth Inst, Dept Med,Div Neurol, Edmonton, AB, Canada

[2] Univ Cambridge, Cambridge Biomed Campus, Cambridge Stem Cell Inst, Wellcome Trust Med Res Council, Cambridge, England

[3] Oregon Hlth & Sci Univ, Jungers Ctr Neurosci Res, Dept Neurol, Portland, OR 97201 USA

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2019年 / 12卷

关键词：

remyelination; microglia; oligodendrocyte; oligodendrocyte progenitor cells; astrocytes; white matter disease; aging; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; OLIGODENDROCYTE PRECURSOR CELLS; SPINAL-CORD-INJURY; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CUPRIZONE-INDUCED DEMYELINATION; MULTIPLE-SCLEROSIS LESIONS; AGE-RELATED-CHANGES; WHITE-MATTER; PROGENITOR CELLS; CNS REMYELINATION;

D O I：

10.3389/fnmol.2019.00225

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that surrounds axons, a process known as demyelination. The spontaneous regeneration of myelin, called remyelination, is associated with restoration of function and prevention of axonal degeneration. Boosting remyelination with therapeutic intervention is a promising new approach that is currently being tested in several clinical trials. The endogenous regulation of remyelination is highly dependent on the immune response. In this review article, we highlight the cell biology of remyelination and its regulation by innate immune cells. For the purpose of this review, we discuss the roles of microglia, and also astrocytes and oligodendrocyte progenitor cells (OPCs) as they are being increasingly recognized to have immune cell functions.

引用

页数：18

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