HBF4-catalyzed Biginelli reaction: One-pot synthesis of dihydropyrimidin-2(1H)-ones under solvent-free conditions

被引：64

作者：

Chen, WeiYi ^{[1
]}

Qin, SuDong

Jin, JianRong

机构：

[1] Suzhou Univ, Coll Chem & Chem Engn, Suzhou 215123, Peoples R China

[2] JiangShan Pharmaceut Corp, Tech Dept, JingJiang 214500, Peoples R China

来源：

CATALYSIS COMMUNICATIONS | 2007年 / 8卷 / 02期

关键词：

Biginelli reaction; fluoroboric acid; solvent-free; dihydropyrimidin-2(1H)-ones;

D O I：

10.1016/j.catcom.2006.05.026

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An efficient synthesis of dihydropyrimidinones from the aldehyde, 1,3-dicarbonyl compound and urea (thiourea) under solvent-free conditions, using fluoroboric acid as the catalyst, is described. Compared with the classical Biginelli reaction conditions, this new protocol has the advantage of high yields, short reaction time and simplicity in the experimental procedure. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：123 / 126

页数：4

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