Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides

被引:55
作者
Musa-Veloso, Kathy [1 ]
Binns, Malcolm Angus [2 ]
Kocenas, Alexandra Catherine [1 ]
Poon, Theresa [1 ]
Elliot, Julie Ann [1 ]
Rice, Harry [3 ]
Oppedal-Olsen, Hilde [4 ]
Lloyd, Hilary [5 ]
Lemke, Shawna [6 ]
机构
[1] Cantox Hlth Sci Int, Mississauga, ON, Canada
[2] Univ Toronto, Toronto, ON, Canada
[3] Global Org EPA & DHA Omega 3s, Salt Lake City, UT USA
[4] Denomega Nutrit Oils AS, Sarpsborg, Norway
[5] Ocean Nutr Canada, Dartmouth, NS, Canada
[6] Monsanto Co, St Louis, MO USA
关键词
docosahexaenoic acid; eicosapentaenoic acid; fish oil; omega-3 fatty acids; triglycerides; CARDIOVASCULAR-DISEASE RISK; POLYUNSATURATED FATTY-ACIDS; STABLE FISH-OIL; BLOOD-LIPIDS; FOLLOW-UP; SUPPLEMENTATION; WOMEN; RESPONSES; MARKERS; TRIACYLGLYCEROL;
D O I
10.1111/j.1753-4887.2010.00272.x
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The objectives of this review were to determine whether the long-chain omega-3 fatty acids eicosapentaenoic acid and/or docosahexaenoic acid dose-dependently reduce fasting serum triglycerides (TG) and, if so, to create a mathematical model that may be used to predict potential percent reductions in fasting serum TG levels at the recommended intakes of 200-500 mg/day. The assessment included 15 randomized controlled trials that met pre-defined inclusion and exclusion criteria. Across these 15 studies, the dose-response was modeled using a first-order elimination curve. The response variable was defined as percent change from baseline in fasting serum TG, adjusted for the placebo effect. A weighting factor equal to the product of each study's sample size and quality score was used. Using the equation of the dose-response curve, predicted reductions in fasting serum TG levels at the recommended long-chain omega-3 fatty acid intakes of 200-500 mg/day are 3.1 to 7.2%. (C) 2010 Cantox Health Sciences Inc. Journal compilation (C) 2010 International Life Sciences Institute
引用
收藏
页码:155 / 167
页数:13
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