Detection of early breast cancer beyond mammographic screening: a promising biomarker panel

被引：14

作者：

Hamann, Moritz ^{[1
]}

Grill, Sabine ^{[2
]}

Struck, Joachim ^{[3
]}

Bergmann, Andreas ^{[3
]}

Hartmann, Oliver ^{[3
]}

Poelcher, Martin ^{[1
]}

Kiechle, Marion ^{[2
]}

机构：

[1] Red Cross Hosp Munich, Dept Gynecol, Taxisstr 3, D-80637 Munich, Germany

[2] Tech Univ Munich, Dept Gynecol & Obstet, Ismaninger Str 22, D-81675 Munich, Germany

[3] Sphingotec GmbH, Neuendorfstr 15A, D-16761 Hennigsdorf, Germany

来源：

BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 13期

关键词：

biomarkers; breast cancer; CA15-3; early detection; enkephalin; human growth hormone; mammographic screening; substance-P; OPIOID GROWTH-FACTOR; FACTOR RECEPTOR AXIS; LIFE-STYLE FACTORS; SUBSTANCE-P; METHIONINE-ENKEPHALIN; POOLED ANALYSIS; CA; 15-3; HORMONE; RISK; EXPRESSION;

D O I：

10.2217/bmm-2019-0085

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: We assessed the suitability of a biomarker panel to improve early detection and individual risk assessment in breast cancer (BC) patients. Materials & methods: PENK, pro-SP, hGH and CA15-3 of 204 BC patients and 68 healthy controls were measured. Results: PENK and human growth hormone concentrations were significantly lower and pro-SP values higher in BC patients compared with controls. C-index increased from 0.628 for CA15-3 alone to 0.754 when all three biomarkers were added to the model. Conclusion: This biomarker panel may improve early detection of BC and influence the assessment of breast imaging. It might be useful for a risk-adapted cancer surveillance or primary prevention program by a more precise determination of an individualized BC risk.

引用

页码：1107 / 1117

页数：11

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