Reflectance Confocal Microscopy-State-of-Art and Research Overview

被引:61
作者
Hofmann-Wellenhof, Rainer [1 ]
Wurm, Elisabeth M. T. [1 ]
Ahlgrimm-Siess, Verena [1 ]
Richtig, Erika [1 ]
Koller, Silvia [1 ]
Smolle, Josef [2 ]
Gerger, Armin [3 ]
机构
[1] Med Univ Graz, Dept Dermatol, A-8010 Graz, Austria
[2] Med Univ Graz, Inst Med Informat Stat & Documentat, A-8010 Graz, Austria
[3] Med Univ Graz, Dept Innere Med, Div Oncol, A-8010 Graz, Austria
关键词
SCANNING LASER MICROSCOPY; MELANOCYTIC SKIN-LESIONS; IN-VIVO DIAGNOSIS; MALIGNANT-MELANOMA; CLINICAL-DIAGNOSIS; SPITZ NEVI; ACCURACY; DERMOSCOPY; BENIGN; APPLICABILITY;
D O I
10.1016/j.sder.2009.06.004
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Reflectance confocal microscopy (RCM) enables in vivo imaging of human skin at a quasi histologic resolution. The black-and-white RCM images show horizontal sections of the skin, at a maximum depth of 350 mu m. To date, the RCM features of a significant number of skin conditions have been described. The main focus of the research community investigating RCM, however, lies on describing and diagnosing melanocytic skin lesions. Taking into account all RCM studies dealing with diagnostic accuracy in melanocytic skin lesions, sensitivity and specificity of approximately 90% and 86% could be found. Improvement of diagnostic accuracy, improved assessment of dermoscopic-histologic correlation, in vivo biopsy side selection, surgical margin assessment, and response control of conservative therapies in skin diseases are some of the major advantages of this novel imaging method. Additionally, RCM holds inherent potential for teledermatologic application and automated image analyzing. This article describes morphologic features of diverse skin lesions and features of "normal skin," summarizes diagnostic advances of RCM, compares studies dealing with diagnostic applicability, and discusses further research goals of this exciting new imaging technique. Semin Cutan Med Surg 28:172-179 (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:172 / 179
页数:8
相关论文
共 38 条
[1]  
AGERO AL, 2008, REFLECTANCE CONFOCAL, P61
[2]   In vivo confocal scanning laser microscopy of common naevi with globular, homogeneous and reticular pattern in dermoscopy [J].
Ahlgrimm-Siess, V. ;
Massone, C. ;
Koller, S. ;
Fink-Puches, R. ;
Richtig, E. ;
Wolf, I. ;
Gerger, A. ;
Hofmann-Wellenhof, R. .
BRITISH JOURNAL OF DERMATOLOGY, 2008, 158 (05) :1000-1007
[3]   Monitoring efficacy of cryotherapy for superficial basal cell carcinomas with in vivo reflectance confocal microscopy: A preliminary study [J].
Ahlgrimm-Siess, Verena ;
Horn, Michael ;
Koller, Silvia ;
Ludwig, Ralf ;
Gerger, Armin ;
Hofmann-Wellenhof, Rainer .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2009, 53 (01) :60-64
[4]  
Astner S, 2008, REFLECTANCE CONFOCAL, P49
[5]   EPILUMINESCENCE MICROSCOPY - A USEFUL TOOL FOR THE DIAGNOSIS OF PIGMENTED SKIN-LESIONS FOR FORMALLY TRAINED DERMATOLOGISTS [J].
BINDER, M ;
SCHWARZ, M ;
WINKLER, A ;
STEINER, A ;
KAIDER, A ;
WOLFF, K ;
PEHAMBERGER, H .
ARCHIVES OF DERMATOLOGY, 1995, 131 (03) :286-291
[6]   Detection of intraepidermal malignant melanoma in vivo by confocal scanning laser microscopy [J].
Busam, KJ ;
Charles, C ;
Lohmann, CM ;
Marghoob, A ;
Goldgeier, M ;
Halpern, AC .
MELANOMA RESEARCH, 2002, 12 (04) :349-355
[7]   Morphologic features of melanocytes, pigmented keratinocytes, and melanophages by in vivo confocal scanning laser microscopy [J].
Busam, KJ ;
Charles, C ;
Lee, G ;
Halpern, AC .
MODERN PATHOLOGY, 2001, 14 (09) :862-868
[8]  
Busam KJ, 2001, ARCH DERMATOL, V137, P923
[9]   Use of in vivo confocal microscopy in malignant melanoma -: An aid in diagnosis and assessment of surgical, and nonsurgical therapeutic approaches [J].
Curiel-Lewandrowski, C ;
Williams, CM ;
Swindells, KJ ;
Tahan, SR ;
Astner, S ;
Frankenthaler, RA ;
González, S .
ARCHIVES OF DERMATOLOGY, 2004, 140 (09) :1127-+
[10]   In vivo confocal laser scanning microscopy of melanocytic skin tumours:: diagnostic applicability using unselected tumour images [J].
Gerger, A. ;
Hofmann-Wellenhof, R. ;
Langsenlehner, U. ;
Richtig, E. ;
Koller, S. ;
Weger, W. ;
Ahlgrimm-Siess, V. ;
Horn, M. ;
Samonigg, H. ;
Smolle, J. .
BRITISH JOURNAL OF DERMATOLOGY, 2008, 158 (02) :329-333