Stereoselective [2,3]-Wittig rearrangement of (1S,2R)-1-amino-indan-2-ol derived amide enolates

被引：26
作者：
Kress, MH
Yang, CH
Yasuda, N
Grabowski, EJJ
机构：
[1] Department of Process Research, Merck Research Laboratories, Merck and Co., Inc., Rahway, NJ 07065
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 15期
关键词：
D O I：
10.1016/S0040-4039(97)00438-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, diastereoselective [2,3]-Wittig rearrangement of alpha-allyloxyamide enolates has been developed using (IS,2R)-1-amino-indan-2-ol as a chiral auxiliary. After auxiliary removal, the resultant optically active alpha-hydroxy acids have been transformed to functionalized amino acid derivatives. (C) 1997 Elsevier Science Ltd.
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页码：2633 / 2636
页数：4
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