Survival Analysis of 3 Different Age Groups and Prognostic Factors among 402 Patients with Skeletal High-Grade Osteosarcoma. Real World Data from a Single Tertiary Sarcoma Center

被引：16

作者：

Evenhuis, Richard E. ^{[1
]}

Acem, Ibtissam ^{[1
,2
]}

Rueten-Budde, Anja J. ^{[3
]}

Karis, Diederik S. A. ^{[1
]}

Fiocco, Marta ^{[3
]}

Dorleijn, Desiree M. J. ^{[1
]}

Speetjens, Frank M. ^{[4
]}

Anninga, Jakob ^{[5
]}

Gelderblom, Hans ^{[4
]}

van de Sande, Michiel A. J. ^{[1
,5
]}

机构：

[1] Leiden Univ, Dept Orthoped Surg, Med Ctr, NL-2300 RC Leiden, Netherlands

[2] Erasmus MC Canc Inst, Dept Surg Oncol & Gastrointestinal Surg, NL-3000 CB Rotterdam, Netherlands

[3] Leiden Univ, Dept Biomed Data Sci, Sect Med Stat & Bioinformat, Math Inst, NL-2300 RC Leiden, Netherlands

[4] Leiden Univ, Dept Med Oncol, Med Ctr, NL-2300 RC Leiden, Netherlands

[5] Princess Maxima Ctr Pediat Oncol, NL-3720 AC Utrecht, Netherlands

来源：

CANCERS | 2021年 / 13卷 / 03期

关键词：

osteosarcoma; survival; prognosis; age groups; chemotherapy; metastasis; local recurrence;

D O I：

10.3390/cancers13030486

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Age is one of many prognostic factors for overall survival in patients with skeletal osteosarcoma. This retrospective study provides an overview of survival in patients with high-grade osteosarcoma in different age groups. It shows prognostic variables for survival and local control among the overall cohort. In this study, in which 402 patients with skeletal high-grade osteosarcoma were included, poor survival was associated with increasing age. Age groups, tumor size, poor histopathological response, distant metastasis at presentation, and local recurrence were independent prognostic factors associated to overall survival and event-free survival. Differences in outcome among different age groups can be partially explained by patient characteristics and treatment characteristics. Age is a known prognostic factor for many sarcoma subtypes, however in the literature there are limited data on the different risk profiles of different age groups for osteosarcoma survival. This study aims to provide an overview of survival in patients with high-grade osteosarcoma in different age groups and prognostic variables for survival and local control among the entire cohort. In this single center retrospective cohort study, 402 patients with skeletal high-grade osteosarcoma were diagnosed and treated with curative intent between 1978 and 2017 at the Leiden University Medical Center (LUMC). Prognostic factors for survival were analyzed using a Cox proportional hazard model. In this study poor overall survival (OS) and event-free survival (EFS) were associated with increasing age. Age groups, tumor size, poor histopathological response, distant metastasis (DM) at presentation and local recurrence (LR) were important independent prognostic factors influencing OS and EFS. Differences in outcome among different age groups can be partially explained by patient and treatment characteristics.

引用

页码：1 / 13

页数：13

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