Rapid in vivo fingerprinting of nonvolatile compounds in breath by extractive electrospray ionization quadrupole time-of-flight mass spectrometry

被引：205
作者：
Chen, Huanwen
Wortmann, Arno
Zhang, Weihua
Zenobi, Renato
机构：
[1] ETH, Dept Chem & Angew Biowissensch, HCI, CH-8093 Zurich, Switzerland
[2] Jilin Univ, Coll Chem, Changchun 130021, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 04期
关键词：
analytical methods; breath analysis; ion-molecule reactions; mass spectrometry; medicinal chemistry;
D O I：
10.1002/anie.200602942
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A blow-by-blow account: Extractive electrospray ionization (EESI) quadrupole TOF (QTOF) mass spectrometry has been established with a commercial instrument without hardware modification for the rapid analysis of breath without sample pretreatment (see picture). Sulfur-containing compounds can be selectively detected by using silver cationization in the EESI source - a method of interest for in vivo metabolic studies and clinical diagnosis. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：580 / 583
页数：4
相关论文
共 40 条
  • [1] Determination of volatile alkyl sulfides in wastewater by headspace solid-phase microextraction followed by gas chromatography-mass spectrometry
    Abalos, M
    Prieto, X
    Bayona, JM
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2002, 963 (1-2) : 249 - 257
  • [2] Electrospray ionization mass spectrometry fingerprinting of beer
    Araújo, AS
    da Rocha, LL
    Tomazela, DM
    Sawaya, ACHF
    Almeida, RR
    Catharino, RR
    Eberlin, MN
    [J]. ANALYST, 2005, 130 (06) : 884 - 889
  • [3] Cysteinyl leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations
    Baraldi, E
    Carraro, S
    Alinovi, R
    Pesci, A
    Ghiro, L
    Bodini, A
    Piacentini, G
    Zacchello, F
    Zanconato, S
    [J]. THORAX, 2003, 58 (06) : 505 - 509
  • [4] Identification of components responsible for the odor of cigar smoker's breath
    Bazemore, R
    Harrison, C
    Greenberg, M
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (02) : 497 - 501
  • [5] Chiral multidimensional gas chromatography (MDGC) and chiral GC-olfactometry with a double-cool-strand interface: Application to malodors
    Begnaud, F
    Starkenmann, C
    Van de Waalb, M
    Chaintreau, A
    [J]. CHEMISTRY & BIODIVERSITY, 2006, 3 (02) : 150 - 160
  • [6] Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation
    Chen, HW
    Venter, A
    Cooks, RG
    [J]. CHEMICAL COMMUNICATIONS, 2006, (19) : 2042 - 2044
  • [7] Quick determination of malodor-causing fatty acids in manure by capillary electrophoresis
    Chi, FH
    Lin, PHP
    Leu, MH
    [J]. CHEMOSPHERE, 2005, 60 (09) : 1262 - 1269
  • [8] Deery MJ, 1997, RAPID COMMUN MASS SP, V11, P57, DOI 10.1002/(SICI)1097-0231(19970115)11:1<57::AID-RCM772>3.0.CO
  • [9] 2-G
  • [10] DESAEDELEER GG, 1971, ENVIRON SCI TECHNOL, V9, P971
1234