Gastroprotective effects of a new zinc(II)-curcumin complex against pylorus-ligature-induced gastric ulcer in rats

被引：32

作者：

Mei, Xueting ^{[1
]}

Luo, Xiaoju ^{[1
]}

Xu, Sika ^{[1
]}

Xu, Donghui ^{[1
]}

Zheng, Yanping ^{[1
]}

Xu, Shibo ^{[1
]}

Lv, Junyi ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Lab Tradit Chinese Med & Marine Drugs, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2009年 / 181卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Zn(II)-curcumin complex; Antiulcer; NF-kappa B; TGF-beta(1); IL-8; Synergistic effect; NF-KAPPA-B; CURCUMIN; ZINC;

D O I：

10.1016/j.cbi.2009.06.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zn(II)-curcumin, a mononuclear (1:1) zinc complex of curcumin was synthesized and examined for its antiulcer activities against pylorus-ligature-induced gastric ulcer in rats. The structure of Zn(II)-curcumin was identified by elemental analysis, NMR and TG-DTA analysis. It was found that a zinc atom was coordinated through the keto-enol group of curcumin along with one acetate group and one water molecule. Zn(II)-curcumin (12, 24 and 48 mg/kg) dose-dependently blocked gastric lesions, significantly reduced gastric volume, free acidity, total acidity and pepsin, compared with control group (P<0.001) and curcumin alone (24 mg/kg, P<0.05). Reverse transcriptase polymerase chain reaction (RT-PCR) analysis showed that Zn(II)-curcumin markedly inhibited the induction of nuclear factor-kappa B (NF-kappa B). transforming growth factor beta(1) (TGF-beta(1)) and interleukin-8 (IL-8), compared with control group (P<0.05). These findings suggested that Zn(II)-curcumin prevented pylorus-ligation-induced lesions in rat by inhibiting NF-kappa B activation and the subsequent production of proinflammatory cytokines, indicating a synergistic effect between curcumin and zinc. An acute toxicity study showed that mice treated with SDs of Zn(II)-curcumin (2 g/kg) manifested no abnormal signs. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：316 / 321

页数：6

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