Genetic evolution of equine influenza virus strains (H3N8) isolated in France from 1967 to 2015 and the implications of several potential pathogenic factors

被引：24
作者：
Fougerolle, Stephanie [1 ,2 ,3 ,4 ,5 ,9 ]
Legrand, Loic [1 ,2 ,3 ,4 ,5 ]
Lecouturier, Fanny [5 ,7 ]
Sailleau, Corinne [6 ]
Paillot, Romain [2 ,3 ,4 ,5 ,8 ]
Hans, Aymeric [5 ,7 ]
Pronost, Stephane [1 ,2 ,3 ,4 ,5 ]
机构：
[1] LABEO Frank Duncombe, 1 Route Rosel, F-14053 Caen 4, France
[2] Univ Caen Basse Normandie, F-14000 Caen, France
[3] Unite Rech Risques Microbiens U2RM, EA 4655, F-14032 Caen, France
[4] Chair Excellence Equine Immunol, F-14032 Caen, France
[5] Hippolia Fdn, 6 Ave Marechal Montgomery, F-14000 Caen, France
[6] Univ Paris Est, UMR Virol1161, Anses Maisons Alfort Lab Anim Hlth, Maisons Alfort, France
[7] ANSES Dozule Lab Equine Dis, Virol Unit, Goustranville, France
[8] Ctr Prevent Med, Anim Hlth Trust, Lanwades Pk, Kentford CB8 7UU, Newmarket, England
[9] Univ Caen Normandy, BioTARGen, F-14053 Caen 4, France
来源：
VIROLOGY | 2017年 / 505卷
关键词：
Horse; Equine influenza; Antigenic drift; Surveillance; Pathogenicity markers; SURVEILLANCE; RECOGNITION; OUTBREAK; SUBSTITUTIONS; CONTRIBUTES; EPIDEMIC; LESSONS; JAPAN; CHAIN; MAP;
D O I：
10.1016/j.virol.2017.02.003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Equine influenza virus (EIV) is a major respiratory pathogen of horses despite the availability of equine influenza vaccines. This study aimed to determine genetic evolution of EIV strains in France between 1967 to present. A whole genome comparative analysis was also conducted on recent French strains in order to identify potential factors of pathogenicity. Comparison of French EIV sequences with vaccine and worldwide epidemic strains revealed amino acid substitutions in both haemagglutinin (HA) and neuraminidase, especially within the antigenic sites and/or close to receptor binding sites (HA). Amino acid substitutions were also identified in other genes, mainly the polymerase complex proteins and PB1-F2. Viruses belonging to Eurasian and American lineages have circulated until 2003 and Florida sub-lineage Clade 2 strains predominates since 2005. The last French strain (2015) displayed several specificities in HA suggesting the occurrence of antigenic drift with presence of pathogenic markers in the PA and PB1-F2 genes.
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收藏
页码：210 / 217
页数：8
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